• Je něco špatně v tomto záznamu ?

The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer

M. Raudenská, M. Bugajová, D. Kalfeřt, J. Plzák, A. Šubrt, P. Tesařová, M. Masařík

. 2024 ; 1879 (6) : 189216. [pub] 20241113

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc25003553

Heterogeneous cancers that lack strong driver mutations with high penetrance, such as head and neck squamous cell carcinoma (HNSCC), present unique challenges to understanding their aetiology due to the complex interactions between genetics and environmental factors. The interplay between lifestyle factors (such as poor oral hygiene, smoking, or alcohol consumption), the oral and gut microbiome, and host genetics appears particularly important in the context of HNSCC. The complex interplay between the gut microbiota and cancer treatment outcomes has also received increasing attention in recent years. This review article describes the bidirectional communication between the host and the oral/gut microbiome, focusing on microbiome-derived metabolites and their impact on systemic immune responses and the modulation of the tumour microenvironment. In addition, we review the role of host lifestyle factors in shaping the composition of the oral/gut microbiota and its impact on cancer progression and therapy. Overall, this review highlights the rationality of considering the oral/gut microbiota as a critical determinant of cancer therapy outcomes and points to therapeutic opportunities offered by targeting the oral/gut microbiota in the management of HNSCC.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25003553
003      
CZ-PrNML
005      
20250206104416.0
007      
ta
008      
250121s2024 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.bbcan.2024.189216 $2 doi
035    __
$a (PubMed)39542383
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Raudenská, Martina $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University/Kamenice 5, CZ-625 00 Brno, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University/Kamenice 5, 62500 Brno, Czech Republic
245    14
$a The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer / $c M. Raudenská, M. Bugajová, D. Kalfeřt, J. Plzák, A. Šubrt, P. Tesařová, M. Masařík
520    9_
$a Heterogeneous cancers that lack strong driver mutations with high penetrance, such as head and neck squamous cell carcinoma (HNSCC), present unique challenges to understanding their aetiology due to the complex interactions between genetics and environmental factors. The interplay between lifestyle factors (such as poor oral hygiene, smoking, or alcohol consumption), the oral and gut microbiome, and host genetics appears particularly important in the context of HNSCC. The complex interplay between the gut microbiota and cancer treatment outcomes has also received increasing attention in recent years. This review article describes the bidirectional communication between the host and the oral/gut microbiome, focusing on microbiome-derived metabolites and their impact on systemic immune responses and the modulation of the tumour microenvironment. In addition, we review the role of host lifestyle factors in shaping the composition of the oral/gut microbiota and its impact on cancer progression and therapy. Overall, this review highlights the rationality of considering the oral/gut microbiota as a critical determinant of cancer therapy outcomes and points to therapeutic opportunities offered by targeting the oral/gut microbiota in the management of HNSCC.
650    _2
$a lidé $7 D006801
650    12
$a střevní mikroflóra $x imunologie $7 D000069196
650    12
$a nádory hlavy a krku $x imunologie $x mikrobiologie $x patologie $x terapie $7 D006258
650    _2
$a životní styl $7 D008019
650    12
$a dlaždicobuněčné karcinomy hlavy a krku $x mikrobiologie $x patologie $x imunologie $x terapie $7 D000077195
650    12
$a nádorové mikroprostředí $x imunologie $7 D059016
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Bugajová, Maria $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University/Kamenice 5, CZ-625 00 Brno, Czech Republic
700    1_
$a Kalfeřt, David $u Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Motol, First Faculty of Medicine, Charles University, V Uvalu 84, 15006 Prague, Czech Republic
700    1_
$a Plzák, Jan $u Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Motol, First Faculty of Medicine, Charles University, V Uvalu 84, 15006 Prague, Czech Republic
700    1_
$a Šubrt, Adam $u Department of Oncology, Institute of Radiation Oncology, First Faculty of Medicine, Charles University and Bulovka University Hospital, Prague, Czech Republic
700    1_
$a Tesařová, Petra $u Department of Oncology, Institute of Radiation Oncology, First Faculty of Medicine, Charles University and Bulovka University Hospital, Prague, Czech Republic
700    1_
$a Masařík, Michal $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University/Kamenice 5, CZ-625 00 Brno, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University/Kamenice 5, 62500 Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno 60200, Czech Republic; Institute of Pathophysiology, First Faculty of Medicine, Charles University, U Nemocnice 5, CZ-128 53 Prague, Czech Republic. Electronic address: masarik@med.muni.cz
773    0_
$w MED00000723 $t Biochimica et biophysica acta, CR. Reviews on cancer $x 1879-2561 $g Roč. 1879, č. 6 (2024), s. 189216
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39542383 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250121 $b ABA008
991    __
$a 20250206104412 $b ABA008
999    __
$a ok $b bmc $g 2263355 $s 1239560
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 1879 $c 6 $d 189216 $e 20241113 $i 1879-2561 $m Biochimica et biophysica acta, CR. Reviews on cancer $n Biochim Biophys Acta Rev Cancer $x MED00000723
LZP    __
$a Pubmed-20250121

Najít záznam

Citační ukazatele

Možnosti archivace