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Comparative analysis of stereotactic radiosurgery outcomes for supratentorial hemangioblastomas in von hippel-lindau disease and sporadic cases: A multi-center international study

SM. Tos, B. Hajikarimloo, G. Mantziaris, A. Shaaban, D. Pham, S. Dayawansa, Z. Wei, LM. McKendrick, A. Niranjan, LD. Lunsford, S. Peker, Y. Samanci, R. Liscak, J. May, D. Mathieu, P. Picozzi, A. Franzini, RE. Warnick, JE. Schoenhals, JD. Palmer,...

. 2024 ; 129 (-) : 110879. [pub] 20241018

Jazyk angličtina

Typ dokumentu časopisecké články, multicentrická studie, srovnávací studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc25003594

BACKGROUND: Hemangioblastomas (HBs) are rare, benign central nervous system (CNS) neoplasms that rarely occur in the supratentorial. Resection with the goal of gross total resection (GTR) is often considered the primary treatment. Stereotactic radiosurgery (SRS) has been utilized more commonly in unresectable or partially resected cases. In this study, we aimed to evaluate SRS's effectiveness and clinical outcomes in supratentorial HBs. METHODS: A retrospective analysis of multi-centers from 1993 to 2022 was conducted on patients with supratentorial HB treated with SRS. RESULTS: The study included 13 patients with 30 supratentorial HBs (24 von Hippel-Lindau (VHL), 6 sporadic). Median age was 26 years. Most tumors were solid (86.2 %). SRS was primary treatment in 86.7 % of cases and adjuvant in 13.3 %. VHL lesions were significantly smaller than sporadic ones (0.2 vs. 3.7 cc, p = 0.009). Median margin dose was higher in VHL cases (17 vs. 13.0 Gy, P = 0.031). For VHL cases, local control (LC) was 100 % at 6 months, 96 % (95 % CI: 88 %, 100 %) from 12 to 60 months post-SRS. For sporadic cases, LC was 100 % at 6 months, 80 % (95 % CI: 52 %, 100 %) from 12 to 60 months post-SRS (p = 0.39). No adverse radiation events or mortality occurred. CONCLUSION: SRS demonstrated a promising role in the clinical course of supratentorial HBs. It can be considered an effective alternative to surgical resection and even a first-line therapeutic option in appropriately selected cases.

Citace poskytuje Crossref.org

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$a Tos, Salem M $u Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA. Electronic address: salem.m.97@hotmail.com
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$a Comparative analysis of stereotactic radiosurgery outcomes for supratentorial hemangioblastomas in von hippel-lindau disease and sporadic cases: A multi-center international study / $c SM. Tos, B. Hajikarimloo, G. Mantziaris, A. Shaaban, D. Pham, S. Dayawansa, Z. Wei, LM. McKendrick, A. Niranjan, LD. Lunsford, S. Peker, Y. Samanci, R. Liscak, J. May, D. Mathieu, P. Picozzi, A. Franzini, RE. Warnick, JE. Schoenhals, JD. Palmer, Z. Xu, JP. Sheehan
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$a BACKGROUND: Hemangioblastomas (HBs) are rare, benign central nervous system (CNS) neoplasms that rarely occur in the supratentorial. Resection with the goal of gross total resection (GTR) is often considered the primary treatment. Stereotactic radiosurgery (SRS) has been utilized more commonly in unresectable or partially resected cases. In this study, we aimed to evaluate SRS's effectiveness and clinical outcomes in supratentorial HBs. METHODS: A retrospective analysis of multi-centers from 1993 to 2022 was conducted on patients with supratentorial HB treated with SRS. RESULTS: The study included 13 patients with 30 supratentorial HBs (24 von Hippel-Lindau (VHL), 6 sporadic). Median age was 26 years. Most tumors were solid (86.2 %). SRS was primary treatment in 86.7 % of cases and adjuvant in 13.3 %. VHL lesions were significantly smaller than sporadic ones (0.2 vs. 3.7 cc, p = 0.009). Median margin dose was higher in VHL cases (17 vs. 13.0 Gy, P = 0.031). For VHL cases, local control (LC) was 100 % at 6 months, 96 % (95 % CI: 88 %, 100 %) from 12 to 60 months post-SRS. For sporadic cases, LC was 100 % at 6 months, 80 % (95 % CI: 52 %, 100 %) from 12 to 60 months post-SRS (p = 0.39). No adverse radiation events or mortality occurred. CONCLUSION: SRS demonstrated a promising role in the clinical course of supratentorial HBs. It can be considered an effective alternative to surgical resection and even a first-line therapeutic option in appropriately selected cases.
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$a Hajikarimloo, Bardia $u Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
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$a Mantziaris, Georgios $u Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
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$a Shaaban, Ahmed $u Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
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$a Pham, Duy $u Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
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$a Dayawansa, Sam $u Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
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$a Wei, Zhishuo $u Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
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$a McKendrick, Lindsay M $u Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
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$a Niranjan, Ajay $u Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
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$a Lunsford, L Dade $u Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
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$a Peker, Selcuk $u Department of Neurological Surgery, Koc University School of Medicine, Istanbul, Turkey
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$a Samanci, Yavuz $u Department of Neurological Surgery, Koc University School of Medicine, Istanbul, Turkey
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$a Liscak, Roman $u Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic
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$a May, Jaromir $u Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic
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$a Mathieu, David $u Department of Neurological Surgery, Université de Sherbrooke, Centre de recherche du CHUS, Canada
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$a Picozzi, Piero $u Department of Neurological Surgery, IRCCS Humanitas Research Hospital, Milan, Italy
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$a Franzini, Andrea $u Department of Neurological Surgery, IRCCS Humanitas Research Hospital, Milan, Italy
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$a Warnick, Ronald E $u Gamma Knife Center, Jewish Hospital, Mayfield Clinic, Cincinnati, OH, USA
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$a Schoenhals, Jonathan E $u Department of Radiation Oncology, The Ohio State University, OH, USA
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$a Palmer, Joshua D $u Department of Radiation Oncology, The Ohio State University, OH, USA
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$a Xu, Zhiyuan $u Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
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$a Sheehan, Jason P $u Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA. Electronic address: jsheehan@virginia.edu
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