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Intraday repeatability of macular layers measurements in glaucomatous and non-glaucomatous patients using spectral-domain optical coherence tomography
V. Makhmutov, W. Adler, PAW. Matos, A. Kopecky, J. Nemcansky, AC. Rokohl, LM. Heindl
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, srovnávací studie
Grantová podpora
DFG
Deutsche Forschungsgemeinschaft
FI 773/15-1
Deutsche Forschungsgemeinschaft
Gerok Programme
Medizinische Fakultät, Universität zu Köln
NLK
ProQuest Central
od 1997-10-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2009-07-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-10-01 do Před 1 rokem
- MeSH
- dospělí MeSH
- glaukom * diagnóza patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- macula lutea * patologie diagnostické zobrazování MeSH
- následné studie MeSH
- nervová vlákna * patologie MeSH
- nitrooční tlak * fyziologie MeSH
- oční hypertenze diagnóza patofyziologie MeSH
- optická koherentní tomografie * metody MeSH
- reprodukovatelnost výsledků MeSH
- retinální gangliové buňky * patologie MeSH
- senioři MeSH
- tonometrie oční MeSH
- zraková pole fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
PURPOSE: To assess the intraday repeatability of macular architecture measurements in glaucomatous and non-glaucomatous patients using spectral-domain optical coherence tomography (SD-OCT) and to evaluate the independence from intraindividual intraocular pressure (IOP) fluctuations. METHODS: In this single-center, time-point comparison study, 88 eyes with glaucoma, 53 eyes with ocular hypertension (OHT), and 253 healthy eyes underwent two standardized SD-OCT and intraocular pressure (IOP) measurements on the same day with a 5-h time gap. Bland-Altman plots, intraclass correlation coefficients (ICC), and random-effects model were used to analyze repeatability of entire retinal thickness, retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, and inner nuclear layer measurements. RESULTS: Intraday measurements were highly reproducible in all 3 groups. ICC were greater than 0.90, respectively. The pairwise comparisons of morphometric parameters showed a statistically significant difference (P < 0.001, respectively) between groups (glaucoma vs. control, glaucoma vs. OHT) and a significant influence of time points. No correlation was found between IOP fluctuations and morphometric parameters (P > 0.05, respectively), except for a weak positive correlation with GCL (rho = 0.109, P = 0.031). CONCLUSIONS: The evaluation of macular morphometric parameters of SD-OCT showed a high intraday repeatability and an excellent degree of agreement in glaucoma, ocular hypertension, and healthy groups. The fixed effects of time points were statistically significant. Except for a weak positive correlation of ganglion cell layer, variability did not appear to be affected by intraday IOP changes. Additional research is required to fully understand the impact of IOP fluctuations on macular morphometric parameters, considering the small observed IOP changes.
Clinic of Ophthalmology University Hospital Ostrava Ostrava Czech Republic
Department of Craniofacial Surgery University of Ostrava Faculty of Medicine Ostrava Czech Republic
Citace poskytuje Crossref.org
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