-
Something wrong with this record ?
A possible effect of epidural steroid injection on collage type ii -α1 level in patients with low back pain
Zainab R. Alqaseer, Ajil A. Alzamily, Raad A. Alkhafaji, Emad M. Hussain, Thaier A. Alkhafaji
Language English Country Czech Republic
Digital library NLK
Source
NLK
ROAD: Directory of Open Access Scholarly Resources
from 2011
- MeSH
- Biomarkers analysis MeSH
- Back Pain * drug therapy MeSH
- Glucocorticoids administration & dosage pharmacology therapeutic use MeSH
- Injections, Epidural * methods MeSH
- Clinical Studies as Topic methods MeSH
- Collagen Type II * administration & dosage pharmacology therapeutic use MeSH
- Humans MeSH
- Pain Management methods MeSH
- Radiculopathy etiology drug therapy MeSH
- Bone Regeneration drug effects MeSH
- Check Tag
- Humans MeSH
Background: Low back pain (LBP) is one of the common musckloskeletal diseases and usual treated by epidural steroid injection (ESI). ESIs improve patients' quality of life, reduce lumbar radicular pain, and postpone spinal surgery. The mechanism of improvement is yet unscertain, perhaps involve type α collagen (COL2α) for bone maintenance, hence, we sought to investigate the role of injected steroids in bone healing focusing on the role of COL2α.Methods: All patients in this research were diagnosed by specialists based on their histories and clinical features and associated diseaeses or compiling therapy. Serum samples collected from LBP patients and control group for comparisons.Results: The present study found a significant (<0.0001) increase in the concentration of COL2α in patients with LBP after injection with ESI treatment compared with patients before injection and healthy individuals.Conclusion: ESI helps LBP sufferers by boosting COL2α, which repairs damaged tissues.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25006953
- 003
- CZ-PrNML
- 005
- 20250528160407.0
- 007
- ta
- 008
- 250515s2025 xr d f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.31482/mmsl.2023.044 $2 doi
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Alqaseer, Zainab R. $u College of Medicine, University of AL-Qadisiyah; Al-Diwaniyah, Iraq
- 245 12
- $a A possible effect of epidural steroid injection on collage type ii -α1 level in patients with low back pain / $c Zainab R. Alqaseer, Ajil A. Alzamily, Raad A. Alkhafaji, Emad M. Hussain, Thaier A. Alkhafaji
- 520 3_
- $a Background: Low back pain (LBP) is one of the common musckloskeletal diseases and usual treated by epidural steroid injection (ESI). ESIs improve patients' quality of life, reduce lumbar radicular pain, and postpone spinal surgery. The mechanism of improvement is yet unscertain, perhaps involve type α collagen (COL2α) for bone maintenance, hence, we sought to investigate the role of injected steroids in bone healing focusing on the role of COL2α.Methods: All patients in this research were diagnosed by specialists based on their histories and clinical features and associated diseaeses or compiling therapy. Serum samples collected from LBP patients and control group for comparisons.Results: The present study found a significant (<0.0001) increase in the concentration of COL2α in patients with LBP after injection with ESI treatment compared with patients before injection and healthy individuals.Conclusion: ESI helps LBP sufferers by boosting COL2α, which repairs damaged tissues.
- 650 07
- $a lidé $7 D006801 $2 czmesh
- 650 17
- $a bolesti zad $x farmakoterapie $7 D001416 $2 czmesh
- 650 07
- $a radikulopatie $x etiologie $x farmakoterapie $7 D011843 $2 czmesh
- 650 17
- $a injekce epidurální $x metody $7 D007268 $2 czmesh
- 650 07
- $a management bolesti $x metody $7 D059408 $2 czmesh
- 650 07
- $a glukokortikoidy $x aplikace a dávkování $x farmakologie $x terapeutické užití $7 D005938 $2 czmesh
- 650 17
- $a kolagen typ II $x aplikace a dávkování $x farmakologie $x terapeutické užití $7 D024043 $2 czmesh
- 650 07
- $a regenerace kostí $x účinky léků $7 D001861 $2 czmesh
- 650 07
- $a biologické markery $x analýza $7 D015415 $2 czmesh
- 650 07
- $a klinická studie jako téma $x metody $7 D000068456 $2 czmesh
- 700 1_
- $a Alzamily, Ajil A. $u College of Medicine, University of AL-Qadisiyah; Al-Diwaniyah, Iraq
- 700 1_
- $a Alkhafaji, Raad A. $u Diwaniyah Health Department; Al-Diwaniyah Teaching Hospital, Al-Diwaniyah, Iraq
- 700 1_
- $a Hussain, Emad M. $u Diwaniyah Health Department; Al-Diwaniyah Teaching Hospital, Al-Diwaniyah, Iraq
- 700 1_
- $a Alkhafaji, Thaier A. $u Diwaniyah Health Department; Al-Diwaniyah Teaching Hospital, Al-Diwaniyah, Iraq
- 773 0_
- $t Vojenské zdravotnické listy $x 0372-7025 $g Roč. 94, č. 1 (2025), s. 2-9 $w MED00011116
- 856 41
- $u https://mmsl.cz/artkey/mms-202501-0001_a-possible-effect-of-epidural-steroid-injection-on-collage-type-ii-8211-945-1-level-in-patients-with-low-ba.php $y plný text volně přístupný
- 910 __
- $a ABA008 $b A 3 $c 1073 $y p $z 0
- 990 __
- $a 20250311 $b ABA008
- 991 __
- $a 20250528160406 $b ABA008
- 999 __
- $a ok $b bmc $g 2324008 $s 1244018
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2025 $b 94 $c 1 $d 2-9 $e 20250303 $i 0372-7025 $m Vojenské zdravotnické listy $x MED00011116
- LZP __
- $c NLK192 $d 20250528 $b NLK111 $a Actavia-MED00011116-20250311
