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Atherosclerotic cardiovascular complications in patients with inflammatory bowel disease
Ondřej Kučerka, Martin Malý, Petra Mináriková, Jan M. Horáček
Language English Country Czech Republic
Digital library NLK
Source
NLK
ROAD: Directory of Open Access Scholarly Resources
from 2011
- MeSH
- Atherosclerosis * etiology MeSH
- Biomarkers analysis MeSH
- Inflammatory Bowel Diseases * complications physiopathology MeSH
- Cardiovascular Diseases etiology MeSH
- Humans MeSH
- Oxidative Stress MeSH
- Risk Factors MeSH
- Inflammation complications physiopathology MeSH
- Check Tag
- Humans MeSH
Inflammatory bowel disease (IBD) is associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD). This article reviews the epidemiology, pathophysiology, risk factors and treatment implications of ASCVD in IBD patients. A number of processes are involved in the increased risk of ASCVD, including inflammation, endothelial dysfunction, hypercoagulability, platelet abnormalities, dyslipidaemia, gut microbiome abnormalities and the use of corticosteroids. While the precise pathophysiology remains complex, the management of inflammation and cardiovascular risk factors is essential to reduce the risk of atherosclerosis in IBD patients. Collaboration between gastroenterologists and preventive cardiologists is emphasised for risk factor management and promotion of disease remission.
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- $a Inflammatory bowel disease (IBD) is associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD). This article reviews the epidemiology, pathophysiology, risk factors and treatment implications of ASCVD in IBD patients. A number of processes are involved in the increased risk of ASCVD, including inflammation, endothelial dysfunction, hypercoagulability, platelet abnormalities, dyslipidaemia, gut microbiome abnormalities and the use of corticosteroids. While the precise pathophysiology remains complex, the management of inflammation and cardiovascular risk factors is essential to reduce the risk of atherosclerosis in IBD patients. Collaboration between gastroenterologists and preventive cardiologists is emphasised for risk factor management and promotion of disease remission.
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