• Something wrong with this record ?

Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults

J. Lian, M. Crowe, KJ. Anstey, KM. Kiely, A. Luisa Dávila, R. Andel

. 2025 ; 80 (4) : . [pub] 20250312

Language English Country United States

Document type Journal Article

Grant support
R01 AG064769 NIA NIH HHS - United States
FL190100011 ARC Laureate Fellowship
CE170100005 Australian Research Council Centre of Excellence in Population Ageing Research

OBJECTIVES: This study examined the association between childhood adversity and late-life cognitive outcomes among older Puerto Rican adults. METHODS: Data were from the Puerto Rican Elder: Health Conditions study, a population-based cohort of 3,713 older Puerto Rican adults (mean age 72.5 years; 60% female). Adverse childhood experiences were categorized into four factors: economic hardship, parental illiteracy, childhood illness, and neighborhood disadvantage. Cognition was assessed with the Mini-Mental Cabán (MMC). For our analyses, cognitive impairment was defined as scoring 1.5 standard deviations below the expected score, adjusted for age, sex, education, and reading ability. Ordinal logistic regression (baseline) and generalized linear mixed models (all 3 waves) analyzed MMC scores; generalized estimating equations assessed incident cognitive impairment (Waves 2 and 3). RESULTS: All four adversity factors were associated with poorer MMC scores at baseline. Parental illiteracy (β = -0.35, p < .001) and neighborhood disadvantage (β = -0.27, p < .001) showed stronger associations than economic hardship (β = -0.10, p = .003) and childhood illness (β = -0.21, p < .001). No factors were significantly related to changes in cognitive scores over time. Depressive symptoms and self-rated health partially mediated cross-sectional relationships, with depressive symptoms showing a stronger effect. All adversity factors except economic hardship were linked to baseline cognitive impairment (OR = 1.42 parent illiteracy, OR = 1.24 childhood illness, OR = 1.82 neighborhood disadvantage, p < .05). Only neighborhood disadvantage was associated with incident cognitive impairment (OR = 1.19, p = .003). DISCUSSION: This study highlights the lasting effect of childhood adversity on late-life cognitive health among older Puerto Ricans, suggesting that addressing early adversity may promote cognitive health later in life.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25009511
003      
CZ-PrNML
005      
20250429134724.0
007      
ta
008      
250415s2025 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1093/geronb/gbae199 $2 doi
035    __
$a (PubMed)39673803
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Lian, James $u School of Psychology, University of New South Wales, Sydney, New South Wales, Australia $u Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, Arizona, USA $1 https://orcid.org/0000000297580472
245    10
$a Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults / $c J. Lian, M. Crowe, KJ. Anstey, KM. Kiely, A. Luisa Dávila, R. Andel
520    9_
$a OBJECTIVES: This study examined the association between childhood adversity and late-life cognitive outcomes among older Puerto Rican adults. METHODS: Data were from the Puerto Rican Elder: Health Conditions study, a population-based cohort of 3,713 older Puerto Rican adults (mean age 72.5 years; 60% female). Adverse childhood experiences were categorized into four factors: economic hardship, parental illiteracy, childhood illness, and neighborhood disadvantage. Cognition was assessed with the Mini-Mental Cabán (MMC). For our analyses, cognitive impairment was defined as scoring 1.5 standard deviations below the expected score, adjusted for age, sex, education, and reading ability. Ordinal logistic regression (baseline) and generalized linear mixed models (all 3 waves) analyzed MMC scores; generalized estimating equations assessed incident cognitive impairment (Waves 2 and 3). RESULTS: All four adversity factors were associated with poorer MMC scores at baseline. Parental illiteracy (β = -0.35, p < .001) and neighborhood disadvantage (β = -0.27, p < .001) showed stronger associations than economic hardship (β = -0.10, p = .003) and childhood illness (β = -0.21, p < .001). No factors were significantly related to changes in cognitive scores over time. Depressive symptoms and self-rated health partially mediated cross-sectional relationships, with depressive symptoms showing a stronger effect. All adversity factors except economic hardship were linked to baseline cognitive impairment (OR = 1.42 parent illiteracy, OR = 1.24 childhood illness, OR = 1.82 neighborhood disadvantage, p < .05). Only neighborhood disadvantage was associated with incident cognitive impairment (OR = 1.19, p = .003). DISCUSSION: This study highlights the lasting effect of childhood adversity on late-life cognitive health among older Puerto Ricans, suggesting that addressing early adversity may promote cognitive health later in life.
650    _2
$a lidé $7 D006801
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a senioři $7 D000368
650    12
$a nepříznivé zkušenosti z dětství $x statistika a číselné údaje $7 D000076783
650    12
$a kognitivní dysfunkce $x epidemiologie $x etnologie $x etiologie $7 D060825
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a chudoba $x statistika a číselné údaje $x psychologie $7 D011203
650    _2
$a charakteristiky okolí bydliště $7 D000091542
650    _2
$a gramotnost $x statistika a číselné údaje $7 D000067010
651    _2
$a Portoriko $x etnologie $x epidemiologie $7 D011647
655    _2
$a časopisecké články $7 D016428
700    1_
$a Crowe, Michael $u Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA $1 https://orcid.org/0000000177364441
700    1_
$a Anstey, Kaarin J $u School of Psychology, University of New South Wales, Sydney, New South Wales, Australia $u UNSW Ageing Futures Institute, University of New South Wales, Sydney, New South Wales, Australia $1 https://orcid.org/0000000297069316
700    1_
$a Kiely, Kim M $u School of Psychology, University of New South Wales, Sydney, New South Wales, Australia $u School of Mathematics and Applied Statistics and School of Health and Society, University of Wollongong, Wollongong, New South Wales, Australia
700    1_
$a Luisa Dávila, Ana $u School of Public Health, University of Puerto Rico, Río Piedras, Puerto Rico
700    1_
$a Andel, Ross $u Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, Arizona, USA $u Memory Clinic, Department of Neurology, 2nd Medical Faculty, Motol Hospital and Charles University, Prague, Czech Republic
773    0_
$w MED00003054 $t The journals of gerontology. Series B, Psychological sciences and social sciences $x 1758-5368 $g Roč. 80, č. 4 (2025)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39673803 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250415 $b ABA008
991    __
$a 20250429134720 $b ABA008
999    __
$a ok $b bmc $g 2311101 $s 1246592
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2025 $b 80 $c 4 $e 20250312 $i 1758-5368 $m The journals of gerontology. Series B, Psychological sciences and social sciences $n J Gerontol B Psychol Sci Soc Sci $x MED00003054
GRA    __
$a R01 AG064769 $p NIA NIH HHS $2 United States
GRA    __
$a FL190100011 $p ARC Laureate Fellowship
GRA    __
$a CE170100005 $p Australian Research Council Centre of Excellence in Population Ageing Research
LZP    __
$a Pubmed-20250415

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...