Hippocampal damage mediated by corticosteroids--a neuropsychiatric research challenge
Jazyk angličtina Země Německo Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
11824844
DOI
10.1007/bf03035134
Knihovny.cz E-zdroje
- MeSH
- Alzheimerova nemoc etiologie metabolismus prevence a kontrola MeSH
- antiflogistika škodlivé účinky MeSH
- atrofie chemicky indukované metabolismus patologie MeSH
- degenerace nervu patologie MeSH
- hipokampus metabolismus patologie MeSH
- hydrokortison metabolismus MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- antiflogistika MeSH
- hydrokortison MeSH
There is an increasing evidence that corticosteroids damage the hippocampus in rodents and in primates. Hippocampal atrophy induced by corticosteroids may play an important role in the pathogenesis of a range of neuropsychiatric disorders. Hippocampus is necessary for short-term memory consolidation and HPA axis regulation. Signs of hippocampal damage (HPA dysregulation in combination with memory impairment) are found in affective disorders, Alzheimer's disease and in posttraumatic stress disorder. MRI volumetry reveals reduced hippocampal volume in these diseases. Evidence supporting the "glucocorticoid hypothesis" of psychiatric disorders is reviewed in the first part of the paper. Unresolved questions concerning temporary aspects of neurodegeneration, causality, reversibility, type of damage, factors increasing hippocampal vulnerability, and both pharmacological (CRH antagonists, antiglucocorticoid drugs, GABA-ergic, serotonergic, glutamatergic agents) and non-pharmacological (psychotherapy) treatment approaches are discussed in the second part.
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Arch Gen Psychiatry. 1984 Mar;41(3):279-83 PubMed
Neuropsychopharmacology. 1999 Oct;21(4):474-84 PubMed
Hippocampus. 1992 Oct;2(4):431-5 PubMed
J Neurosci. 1995 Mar;15(3 Pt 1):1768-77 PubMed
Neurosci Lett. 1992 Apr 13;138(1):157-60 PubMed
Neuroscience. 1995 Nov;69(1):83-8 PubMed
J Clin Endocrinol Metab. 1994 Feb;78(2):249-55 PubMed
Science. 1985 Sep 27;229(4720):1397-400 PubMed
Psychol Med. 1997 Jul;27(4):951-9 PubMed
J Neurosci. 1990 Sep;10(9):2897-902 PubMed
Am J Psychiatry. 1995 Jul;152(7):982-6 PubMed
Biol Psychiatry. 1992 Nov 1;32(9):756-65 PubMed
Am J Psychiatry. 2000 Jan;157(1):115-8 PubMed
Am J Psychiatry. 1999 Jun;156(6):816-28 PubMed
J Head Trauma Rehabil. 2000 Jun;15(3):875-94 PubMed
Ann N Y Acad Sci. 1997 Jun 21;821:271-84 PubMed
Psychoneuroendocrinology. 1997;22 Suppl 1:S125-32 PubMed
J Neurosci. 1999 Jun 15;19(12):5034-43 PubMed
Arch Gen Psychiatry. 1985 Dec;42(12):1193-204 PubMed
J Clin Psychopharmacol. 1991 Apr;11(2):121-6 PubMed
J Neurosci. 1994 Apr;14(4):2047-53 PubMed
JAMA. 2000 Aug 2;284(5):592-7 PubMed
J Psychiatr Res. 2000 May-Jun;34(3):171-81 PubMed
Biol Psychiatry. 1999 Dec 1;46(11):1472-9 PubMed
Ann Allergy. 1991 May;66(5):414-9 PubMed
Brain Res. 1992 Aug 21;588(2):341-5 PubMed
Neurobiol Aging. 1997 Mar-Apr;18(2):131-8 PubMed
Eur J Pharmacol. 2000 Sep 29;405(1-3):199-206 PubMed
Am J Psychiatry. 1986 Apr;143(4):442-6 PubMed
J Neurosci. 1986 Aug;6(8):2240-4 PubMed
Neuropsychopharmacology. 2000 Nov;23(5):477-501 PubMed
Eur Neuropsychopharmacol. 1997 Oct;7 Suppl 3:S323-8 PubMed
Life Sci. 1996;58(17):1475-83 PubMed
Am J Psychiatry. 1996 Jul;153(7):886-91 PubMed
Biol Psychiatry. 1999 Apr 15;45(8):1070-4 PubMed
Br Med Bull. 1996 Jul;52(3):597-617 PubMed
Arch Gen Psychiatry. 1998 Jan;55(1):41-6 PubMed
Neuron. 1990 May;4(5):759-65 PubMed
Neuroscience. 1995 Nov;69(1):89-98 PubMed
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3908-13 PubMed
Acta Neurol Scand. 1993 Jan;87(1):52-5 PubMed
J Neurosci. 1996 Apr 1;16(7):2365-72 PubMed
Biol Psychiatry. 1997 Oct 15;42(8):680-6 PubMed
Neurobiol Aging. 1991 Jan-Feb;12(1):31-8 PubMed
Biol Psychiatry. 1985 Mar;20(3):333-7 PubMed
Am J Psychiatry. 1993 Jul;150(7):1015-9 PubMed
Biol Psychiatry. 1999 Dec 15;46(12):1595-602 PubMed
J Neurosci. 1985 May;5(5):1228-32 PubMed
J Clin Psychopharmacol. 1999 Oct;19(5):466-70 PubMed
Drugs. 1991 Nov;42(5):721-9 PubMed
Am J Psychiatry. 1995 Jul;152(7):973-81 PubMed
Arch Gen Psychiatry. 2000 Oct;57(10):925-35 PubMed
Biol Psychiatry. 1996 Dec 1;40(11):1091-9 PubMed
Eur J Pharmacol. 1999 Apr 29;371(2-3):113-22 PubMed
Prog Neurobiol. 1995 Feb;45(2):129-41 PubMed
Biol Psychiatry. 1997 Jan 1;41(1):23-32 PubMed
Am J Psychiatry. 1990 Oct;147(10):1297-303 PubMed
Eur J Pharmacol. 1992 Nov 3;222(1):157-62 PubMed
Am J Psychiatry. 1992 Jan;149(1):45-51 PubMed
Arch Gen Psychiatry. 1995 Sep;52(9):747-55 PubMed
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