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Depressive Symptoms and Amyloid Pathology
WA. Wiels, JE. Oomens, S. Engelborghs, C. Baeken, CAF. von Arnim, M. Boada, M. Didic, B. Dubois, T. Fladby, WM. van der Flier, GB. Frisoni, L. Fröhlich, KD. Gill, T. Grimmer, H. Hildebrandt, J. Hort, Y. Itoh, T. Iwatsubo, A. Klimkowicz-Mrowiec,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
- MeSH
- amyloidní beta-protein * mozkomíšní mok metabolismus MeSH
- apolipoprotein E4 genetika MeSH
- biologické markery mozkomíšní mok MeSH
- deprese * MeSH
- dospělí MeSH
- kognitivní dysfunkce * MeSH
- lidé středního věku MeSH
- lidé MeSH
- peptidové fragmenty mozkomíšní mok MeSH
- pozitronová emisní tomografie * MeSH
- průřezové studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- věkové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
IMPORTANCE: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology. OBJECTIVE: To examine the association between depressive symptoms and amyloid pathology and its dependency on age, sex, education, and APOE genotype in older individuals without dementia. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional analyses were performed using data from the Amyloid Biomarker Study data pooling initiative. Data from 49 research, population-based, and memory clinic studies were pooled and harmonized. The Amyloid Biomarker Study has been collecting data since 2012 and data collection is ongoing. At the time of analysis, 95 centers were included in the Amyloid Biomarker Study. The study included 9746 individuals with normal cognition (NC) and 3023 participants with mild cognitive impairment (MCI) aged between 34 and 100 years for whom data on amyloid biomarkers, presence of depressive symptoms, and age were available. Data were analyzed from December 2022 to February 2024. MAIN OUTCOMES AND MEASURES: Amyloid-β1-42 levels in cerebrospinal fluid or amyloid positron emission tomography scans were used to determine presence or absence of amyloid pathology. Presence of depressive symptoms was determined on the basis of validated depression rating scale scores, evidence of a current clinical diagnosis of depression, or self-reported depressive symptoms. RESULTS: In individuals with NC (mean [SD] age, 68.6 [8.9] years; 5664 [58.2%] female; 3002 [34.0%] APOE ε4 carriers; 937 [9.6%] had depressive symptoms; 2648 [27.2%] had amyloid pathology), the presence of depressive symptoms was not associated with amyloid pathology (odds ratio [OR], 1.13; 95% CI, 0.90-1.40; P = .29). In individuals with MCI (mean [SD] age, 70.2 [8.7] years; 1481 [49.0%] female; 1046 [44.8%] APOE ε4 carriers; 824 [27.3%] had depressive symptoms; 1668 [55.8%] had amyloid pathology), the presence of depressive symptoms was associated with a lower likelihood of amyloid pathology (OR, 0.73; 95% CI 0.61-0.89; P = .001). When considering subgroup effects, in individuals with NC, the presence of depressive symptoms was associated with a higher frequency of amyloid pathology in APOE ε4 noncarriers (mean difference, 5.0%; 95% CI 1.0-9.0; P = .02) but not in APOE ε4 carriers. This was not the case in individuals with MCI. CONCLUSIONS AND RELEVANCE: Depressive symptoms were not consistently associated with a higher frequency of amyloid pathology in participants with NC and were associated with a lower likelihood of amyloid pathology in participants with MCI. These findings were not influenced by age, sex, or education level. Mechanisms other than amyloid accumulation may commonly underlie depressive symptoms in late life.
Ace Alzheimer Center Barcelona Universitat Internacional de Catalunya Barcelona Spain
Banner Alzheimer's Institute Phoenix Arizona
Center for Research and Advanced Therapies Cita Alzheimer Foundation Donostia San Sebastian Spain
Charité Universitätsmedizin Berlin Campus Benjamin Franklin Berlin Deutschland
Clinical Memory Research Unit Department of Clinical Sciences Lund University Lund Sweden
Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden
Cognitive Disorder Research Unit Department of Clinical Sciences Malmö Sweden
Department of Biochemical Diagnostics University Hospital of Białystok Białystok Poland
Department of Biochemistry Postgraduate Institute of Medical Education and Research Chandigarh India
Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy
Department of Biomedical Sciences University of Antwerp Antwerp Belgium
Department of Clinical Medicine University of Copenhagen Copenhagen Denmark
Department of Electrical Engineering Eindhoven University of Technology Eindhoven the Netherlands
Department of Epidemiology Biogen Cambridge Massachusetts
Department of Geriatrics University of Goettingen Medical School Goettingen Germany
Department of Health Sciences University of Genoa Genoa Italy
Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden
Department of Neurodegeneration Diagnostics Medical University of Białystok Białystok Poland
Department of Neurology Akershus University Hospital Lorenskog Norway
Department of Neurology Columbia University New York City New York
Department of Neurology Institute of Clinical Medicine University of Eastern Finland Kuopio Finland
Department of Neurology Mayo Clinic in Florida Jacksonville
Department of Neurology Onze Lieve Vrouw Hospital Aalst Belgium
Department of Neurology Osaka Metropolitan University Graduate School of Medicine Osaka Japan
Department of Neurology University Hospital of Munich Munich Germany
Department of Neurology University Hospital of North Norway Tromsø Norway
Department of Nuclear Medicine Klinikum Bayreuth Bayreuth Germany
Department of Nutrition and Diatetics Harokopio University Kallithea Athens Greece
Department of Old Age Psychiatry Psychology and Neuroscience King's College London United Kingdom
Department of Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany
Department of Psychiatry Faculty of Medicine McGill University Montreal Quebec Canada
Department of Psychiatry Seoul National University College of Medicine Seoul Republic of Korea
Department of Psychology The Arctic University of Norway Tromsø Norway
Department of Psychology University of Gothenburg Gothenburg Sweden
Department of Radiation Oncology Emory University Atlanta Georgia
Department of Radiology Massachusetts General Hospital Boston
Department of Radiology University Medical Center Leiden Leiden the Netherlands
Douglas Mental Health University Institute Montreal Quebec Canada
Faculty of Medicine and Pharmacy Vrije Universiteit Brussel Brussels Belgium
Faculty of Medicine University of Coimbra Coimbra Portugal
Faculty of Medicine University of Lisbon Lisboa Portugal
German Center for Neurodegenerative Diseases Bonn Cologne Germany
German Center for Neurodegenerative Diseases Munich Germany
Graduate School of Medicine and Faculty of Medicine The University of Tokyo Tokyo Japan
Harvard Aging Brain Study Department of Neurology Harvard Medical School Boston Massachusetts
Helen Wills Neuroscience Institute University of California Berkeley
Hong Kong Center for Neurodegenerative Diseases Hong Kong China
Klinikum Bremen Ost University of Oldenburg Institute of Psychology Oldenburg Germany
McConnell Brain Imaging Centre Montreal Neurological Institute Montreal Quebec Canada
Memory Clinic University Hospitals and University of Geneva Geneva Switzerland
Memory Unit Neurology Department Hospital de la Santa Creu i Sant Pau Barcelona Spain
Munich Cluster for Systems Neurology Munich Germany
Neurocenter Department of Neurology Kuopio University Hospital Kuopio Finland
Neurology Unit Department of Clinical and Experimental Sciences University of Brescia Brescia Italy
School of Medical Sciences Örebro University Örebro Sweden
Translational Neuroscience Laboratory McLean Hospital Harvard Medical School Belmont Massachusetts
Turku Positron Emission Tomography Centre University of Turku Turku Finland
United Kingdom Dementia Research Institute London United Kingdom
Citace poskytuje Crossref.org
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- $a Wiels, Wietse A $u Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium $u Department of Neurology, Onze-Lieve-Vrouw Hospital, Aalst, Belgium
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- $a Depressive Symptoms and Amyloid Pathology / $c WA. Wiels, JE. Oomens, S. Engelborghs, C. Baeken, CAF. von Arnim, M. Boada, M. Didic, B. Dubois, T. Fladby, WM. van der Flier, GB. Frisoni, L. Fröhlich, KD. Gill, T. Grimmer, H. Hildebrandt, J. Hort, Y. Itoh, T. Iwatsubo, A. Klimkowicz-Mrowiec, DY. Lee, A. Lleó, P. Martinez-Lage, A. de Mendonça, PT. Meyer, EN. Kapaki, P. Parchi, M. Pardini, L. Parnetti, J. Popp, L. Rami, EM. Reiman, JO. Rinne, KM. Rodrigue, P. Sánchez-Juan, I. Santana, M. Sarazin, N. Scarmeas, I. Skoog, PJ. Snyder, RA. Sperling, S. Villeneuve, A. Wallin, J. Wiltfang, H. Zetterberg, R. Ossenkoppele, FRJ. Verhey, SJB. Vos, PJ. Visser, WJ. Jansen, Amyloid Biomarker Study group, Alzheimer’s Disease Neuroimaging Initiative (ADNI), the A4 Study group, Dominantly Inherited Alzheimer Network (DIAN), European Prevention of Alzheimer’s Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI), Harvard Aging Brain Stud, D. Alcolea, D. Altomare, S. Baiardi, I. Baldeiras, RJ. Bateman, K. Blennow, M. Bottlaender, A. den Braber, MA. van Buchem, MS. Byun, J. Cerman, K. Chen, E. Chipi, GS. Day, A. Drzezga, M. Eckerström, LL. Ekblad, S. Epelbaum, S. Förster, J. Fortea, Y. Freund-Levi, L. Frings, E. Guedj, L. Hausner, S. Hellwig, ED. Huey, JF. Jiménez-Bonilla, KA. Johnson, AI. Juaristi, R. Kandimalla, G. Paraskevas, S. Kern, BS. Kirsebom, J. Kornhuber, J. Lagarde, SM. Landau, N. Legdeur, JJ. Llibre Guerra, NN. Maserejian, M. Marquié, S. Minatani, SD. Morbelli, B. Mroczko, E. Ntanasi, CR. de Oliveira, P. Olivieri, A. Orellana, RJ. Perrin, O. Peters, S. Prabhakar, IH. Ramakers, E. Rodríguez-Rodriguez, A. Ruiz, E. Rüther, P. Selnes, D. Silva, H. Soininen, L. Spiru, A. Takeda, M. Teichmann, BM. Tijms, CE. Teunissen, LI. Thompson, J. Vogelgsangs, J. Vöglein, G. Waldemar, ÅK. Wallin, M. Yannakoulia, D. Yi, A. Zettergren
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- $a IMPORTANCE: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology. OBJECTIVE: To examine the association between depressive symptoms and amyloid pathology and its dependency on age, sex, education, and APOE genotype in older individuals without dementia. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional analyses were performed using data from the Amyloid Biomarker Study data pooling initiative. Data from 49 research, population-based, and memory clinic studies were pooled and harmonized. The Amyloid Biomarker Study has been collecting data since 2012 and data collection is ongoing. At the time of analysis, 95 centers were included in the Amyloid Biomarker Study. The study included 9746 individuals with normal cognition (NC) and 3023 participants with mild cognitive impairment (MCI) aged between 34 and 100 years for whom data on amyloid biomarkers, presence of depressive symptoms, and age were available. Data were analyzed from December 2022 to February 2024. MAIN OUTCOMES AND MEASURES: Amyloid-β1-42 levels in cerebrospinal fluid or amyloid positron emission tomography scans were used to determine presence or absence of amyloid pathology. Presence of depressive symptoms was determined on the basis of validated depression rating scale scores, evidence of a current clinical diagnosis of depression, or self-reported depressive symptoms. RESULTS: In individuals with NC (mean [SD] age, 68.6 [8.9] years; 5664 [58.2%] female; 3002 [34.0%] APOE ε4 carriers; 937 [9.6%] had depressive symptoms; 2648 [27.2%] had amyloid pathology), the presence of depressive symptoms was not associated with amyloid pathology (odds ratio [OR], 1.13; 95% CI, 0.90-1.40; P = .29). In individuals with MCI (mean [SD] age, 70.2 [8.7] years; 1481 [49.0%] female; 1046 [44.8%] APOE ε4 carriers; 824 [27.3%] had depressive symptoms; 1668 [55.8%] had amyloid pathology), the presence of depressive symptoms was associated with a lower likelihood of amyloid pathology (OR, 0.73; 95% CI 0.61-0.89; P = .001). When considering subgroup effects, in individuals with NC, the presence of depressive symptoms was associated with a higher frequency of amyloid pathology in APOE ε4 noncarriers (mean difference, 5.0%; 95% CI 1.0-9.0; P = .02) but not in APOE ε4 carriers. This was not the case in individuals with MCI. CONCLUSIONS AND RELEVANCE: Depressive symptoms were not consistently associated with a higher frequency of amyloid pathology in participants with NC and were associated with a lower likelihood of amyloid pathology in participants with MCI. These findings were not influenced by age, sex, or education level. Mechanisms other than amyloid accumulation may commonly underlie depressive symptoms in late life.
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- $a Oomens, Julie E $u Department of Psychiatry & Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands
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- $a Engelborghs, Sebastiaan $u Vrije Universiteit Brussel, Center for Neurosciences, Neuroprotection & Neuromodulation Research Group, Brussels, Belgium $u Departments of Neurology and Psychiatry and Bru-BRAIN, Universitair Ziekenhuis Brussel, Brussels, Belgium $u Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Lee, Dong Young $u Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
- 700 1_
- $a Lleó, Alberto $u Centre for Biomedical Research Network on Neurodegenerative Diseases, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
- 700 1_
- $a Martinez-Lage, Pablo $u Center for Research and Advanced Therapies, Cita-Alzheimer Foundation, Donostia-San Sebastian, Spain
- 700 1_
- $a de Mendonça, Alexandre $u Faculty of Medicine, University of Lisbon, Lisboa, Portugal
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Villeneuve, Sylvia $u McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec, Canada $u Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada $u Douglas Mental Health University Institute, Montreal, Quebec, Canada
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Ossenkoppele, Rik $u Memory Clinic, University Hospitals and University of Geneva, Geneva, Switzerland $u Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden
- 700 1_
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- 700 1_
- $a Vos, Stephanie J B $u Department of Psychiatry & Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands
- 700 1_
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- 700 1_
- $a Jansen, Willemijn J $u Department of Psychiatry & Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands $u Banner Alzheimer's Institute, Phoenix, Arizona
- 700 1_
- $a Alcolea, Daniel $u Centre for Biomedical Research Network on Neurodegenerative Diseases, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
- 700 1_
- $a Altomare, Daniele $u Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
- 700 1_
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- 700 1_
- $a Baldeiras, Ines $u Faculty of Medicine, University of Coimbra, Coimbra, Portugal $u Center for Neuroscience and Cell Biology, Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal $u Neurology Department and Laboratory of Neurochemistry, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
- 700 1_
- $a Bateman, Randall J $u Department of Neurology and the Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, Missouri
- 700 1_
- $a Blennow, Kaj $u Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
- 700 1_
- $a Bottlaender, Michel $u Paris-Saclay University, BioMaps, Inserm, Commissariat à l'énergie atomique et aux énergies alternatives, Service Hospitalier Frederic Joliot, Orsay, France $u Paris-Saclay University, Research Unit in Clinical and Translational Applicative NeuroImaging, Neurospin, Commissariat à l'énergie atomique et aux énergies alternatives, Gif-sur-Yvette, France
- 700 1_
- $a den Braber, Anouk $u Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Centers location Vrije Universiteit Medical Center, Amsterdam, Amsterdam, the Netherlands
- 700 1_
- $a van Buchem, Mark A $u Department of Radiology, University Medical Center Leiden, Leiden, the Netherlands
- 700 1_
- $a Byun, Min Soo $u Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
- 700 1_
- $a Cerman, Jirí $u Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic
- 700 1_
- $a Chen, Kewei $u Banner Alzheimer's Institute, Phoenix, Arizona
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Eckerström, Marie $u Department of Psychology, University of Gothenburg, Gothenburg, Sweden
- 700 1_
- $a Ekblad, Laura L $u Turku Positron Emission Tomography Centre, University of Turku, Turku, Finland $u Department of Geriatrics, Turku University Hospital, Wellbeing Services County of Southwestern Finland, Turku, Finland
- 700 1_
- $a Epelbaum, Stéphane $u Department of Neurology, Institut de la Mémoire et de la Maladie d'Alzheimer, Centre de Référence Démences Rares, Hôpital de la Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris, Paris, France
- 700 1_
- $a Förster, Stefan $u Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany $u Department of Nuclear Medicine, Klinikum Bayreuth, Bayreuth, Germany
- 700 1_
- $a Fortea, Juan $u Centre for Biomedical Research Network on Neurodegenerative Diseases, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
- 700 1_
- $a Freund-Levi, Yvonne $u School of Medical Sciences, Örebro University, Örebro, Sweden $u Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden $u Department of Old Age Psychiatry, Psychology and Neuroscience, King's College, London, United Kingdom
- 700 1_
- $a Frings, Lars $u Department of Nuclear Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
- 700 1_
- $a Guedj, Eric $u Aix Marseille University, L'Assistance publique-Hôpitaux de Marseille, Centre National de la Recherche Scientifique, Centrale Marseille, Institut Fresnel, Timone Hospital, Centre Européen de Recherche en Imagerie Médicale, Nuclear Medicine Department, Marseille, France
- 700 1_
- $a Hausner, Lucrezia $u Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
- 700 1_
- $a Hellwig, Sabine $u Department of Psychiatry and Psychotherapy Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
- 700 1_
- $a Huey, Edward D $u Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island
- 700 1_
- $a Jiménez-Bonilla, Julio F $u Department of Nuclear Medicine, Marqués de Valdecilla University Hospital and Instituto de Investigación Marqués de Valdecilla, Santander, Spain
- 700 1_
- $a Johnson, Keith A $u Department of Radiology, Massachusetts General Hospital, Boston
- 700 1_
- $a Juaristi, Ane Iriondo $u Center for Research and Advanced Therapies, Cita-Alzheimer Foundation, Donostia-San Sebastian, Spain
- 700 1_
- $a Kandimalla, Ramesh $u Department of Radiation Oncology, Emory University, Atlanta, Georgia $u Applied Biology, Council of Scientific and Industrial Research-Indian Institute of Chemical Technology, Hyderabad, Telangana State, India $u Department of Biochemistry, Kakatiya Medical College/Mahatma Gandhi Memorial Hospital, Warangal, Telangana State, India
- 700 1_
- $a Paraskevas, George $u National and Kapodistrian University of Athens, School of Medicine, 1st Department of Neurology, Eginition Hospital, Athens, Greece
- 700 1_
- $a Kern, Silke $u Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden $u Department of Psychiatry, Cognition and Old Age Psychiatry, Sahlgrenska University Hospital, Västra Götalandsregion, Sweden
- 700 1_
- $a Kirsebom, Bjørn-Eivind S $u Department of Neurology, University Hospital of North Norway, Tromsø, Norway $u Department of Psychology, The Arctic University of Norway, Tromsø, Norway
- 700 1_
- $a Kornhuber, Johannes $u Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
- 700 1_
- $a Lagarde, Julien $u Department of Neurology of Memory and Language, Groupe Hospitalier Universitaire Paris Psychiatry and Neurosciences, Hôpital Sainte Anne, Paris, France $u Paris-Saclay University, BioMaps, Inserm, Commissariat à l'énergie atomique et aux énergies alternatives, Service Hospitalier Frederic Joliot, Orsay, France
- 700 1_
- $a Landau, Susan M $u Helen Wills Neuroscience Institute, University of California, Berkeley
- 700 1_
- $a Legdeur, Nienke $u Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Centers location Vrije Universiteit Medical Center, Amsterdam, Amsterdam, the Netherlands
- 700 1_
- $a Llibre Guerra, Jorge J $u Department of Neurology and the Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, Missouri
- 700 1_
- $a Maserejian, Nancy N $u Department of Epidemiology, Biogen, Cambridge, Massachusetts
- 700 1_
- $a Marquié, Marta $u Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain $u Centre for Biomedical Research Network on Neurodegenerative Diseases, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
- 700 1_
- $a Minatani, Shinobu $u Department of Neurology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
- 700 1_
- $a Morbelli, Silvia Daniela $u Department of Health Sciences, University of Genoa, Genoa, Italy $u Ospedale Policlinico San Martino, Scientific Institute for Research, Hospitalization and Healthcare, Genoa, Italy
- 700 1_
- $a Mroczko, Barbara $u Department of Neurodegeneration Diagnostics, Medical University of Białystok, Białystok, Poland $u Department of Biochemical Diagnostics, University Hospital of Białystok, Białystok, Poland
- 700 1_
- $a Ntanasi, Eva $u Department of Nutrition and Diatetics, Harokopio University, Kallithea, Athens, Greece
- 700 1_
- $a de Oliveira, Catarina Resende $u Center for Neuroscience and Cell Biology, Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
- 700 1_
- $a Olivieri, Pauline $u Paris-Saclay University, BioMaps, Inserm, Commissariat à l'énergie atomique et aux énergies alternatives, Service Hospitalier Frederic Joliot, Orsay, France
- 700 1_
- $a Orellana, Adelina $u Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain $u Centre for Biomedical Research Network on Neurodegenerative Diseases, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
- 700 1_
- $a Perrin, Richard J $u Department of Pathology and Immunology, Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri
- 700 1_
- $a Peters, Oliver $u Charité Universitätsmedizin Berlin-Campus Benjamin Franklin, Berlin, Deutschland
- 700 1_
- $a Prabhakar, Sudesh $u Department of Neurology, Nehru Hospital, Postgraduate Institute of Medical Education and Research, Chandigarh, India
- 700 1_
- $a Ramakers, Inez H $u Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium
- 700 1_
- $a Rodríguez-Rodriguez, Eloy $u Neurology Department, Hospital Universitario Marqués de Valdecilla and Instituto de Investigación Sanitaria Valdecilla, University of Cantabria, Santander, Biomedical Research Networking Center on Neurodegenerative Diseases, Madrid, Santander, Spain
- 700 1_
- $a Ruiz, Agustín $u Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain $u Centre for Biomedical Research Network on Neurodegenerative Diseases, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
- 700 1_
- $a Rüther, Eckart $u Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany
- 700 1_
- $a Selnes, Per $u Department of Neurology, Akershus University Hospital, Lorenskog, Norway
- 700 1_
- $a Silva, Dina $u Faculty of Medicine, University of Lisbon, Lisboa, Portugal
- 700 1_
- $a Soininen, Hilkka $u Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland $u Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
- 700 1_
- $a Spiru, Luiza $u Geriatrics, Gerontology and Old Age Psychiatry Clinical Department, Carol Davila University of Medicine and Pharmacy-Elias, Emergency Clinical Hospital, Bucharest, Romania $u Excellence Center for Memory Diseases, Brain Health and Longevity Medicine, Ana Aslan International Foundation, Bucharest, Romania
- 700 1_
- $a Takeda, Akitoshi $u Department of Neurology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
- 700 1_
- $a Teichmann, Marc $u Department of Neurology, Institut de la Mémoire et de la Maladie d'Alzheimer, Centre de Référence Démences Rares, Hôpital de la Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris, Paris, France
- 700 1_
- $a Tijms, Betty M $u Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Centers location Vrije Universiteit Medical Center, Amsterdam, Amsterdam, the Netherlands
- 700 1_
- $a Teunissen, Charlotte E $u Neurochemistry Lab, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers location Vrije Universiteit Medical Center, Amsterdam, the Netherlands
- 700 1_
- $a Thompson, Loisa I $u Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island
- 700 1_
- $a Vogelgsangs, Jonathan $u Translational Neuroscience Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts
- 700 1_
- $a Vöglein, Jonathan $u Department of Neurology, University Hospital of Munich, Munich, Germany $u German Center for Neurodegenerative Diseases, Munich, Germany $u Munich Cluster for Systems Neurology, Munich, Germany
- 700 1_
- $a Waldemar, Gunhild $u Danish Dementia Research Center, Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark $u Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
- 700 1_
- $a Wallin, Åsa K $u Cognitive Disorder Research Unit, Department of Clinical Sciences, Malmö, Sweden
- 700 1_
- $a Yannakoulia, Mary $u Department of Nutrition and Diatetics, Harokopio University, Kallithea, Athens, Greece
- 700 1_
- $a Yi, Dahyun $u Institute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, Republic of Korea
- 700 1_
- $a Zettergren, Anna $u Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
- 710 2_
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- 710 2_
- $a Alzheimer’s Disease Neuroimaging Initiative (ADNI), the A4 Study group, Dominantly Inherited Alzheimer Network (DIAN), European Prevention of Alzheimer’s Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI), Harvard Aging Brain Stud
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