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Revealing connectivity patterns of deep brain stimulation efficacy in Parkinson's disease

E. Výtvarová, M. Lamoš, J. Hlinka, S. Goldemundová, I. Rektor, M. Bočková

. 2024 ; 14 (1) : 31652. [pub] 20241230

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc25010547

Grantová podpora
GAČR 21-25953S Grantová Agentura České Republiky
GAČR 21-25953S Grantová Agentura České Republiky
GAČR 21-25953S Grantová Agentura České Republiky
GAČR 21-25953S Grantová Agentura České Republiky
GAČR 21-25953S Grantová Agentura České Republiky
NU21-04-00445 Agentura Pro Zdravotnický Výzkum České Republiky
NU21-04-00445 Agentura Pro Zdravotnický Výzkum České Republiky
NU21-04-00445 Agentura Pro Zdravotnický Výzkum České Republiky
NU21-04-00445 Agentura Pro Zdravotnický Výzkum České Republiky
ID Project No. LX22NPO5107 National Institute for Neurological Research-Programme EXCELES
ID Project No. LX22NPO5107 National Institute for Neurological Research-Programme EXCELES
ID Project No. LX22NPO5107 National Institute for Neurological Research-Programme EXCELES
NUDZ, 00023752 institutional program of support MH CZ - DRO

The aim of this work was to study the effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) on the subnetwork of subcortical and cortical motor regions and on the whole brain connectivity using the functional connectivity analysis in Parkinson's disease (PD). The high-density source space EEG was acquired and analyzed in 43 PD subjects in DBS on and DBS off stimulation states (off medication) during a cognitive-motor task. Increased high gamma band (50-100 Hz) connectivity within subcortical regions and between subcortical and cortical motor regions was significantly associated with the Movement Disorders Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III improvement after DBS. Whole brain neural correlates of cognitive performance were also detected in the high gamma (50-100 Hz) band. A whole brain multifrequency connectivity profile was found to classify optimal and suboptimal responders to DBS with a positive predictive value of 0.77, negative predictive value of 0.55, specificity of 0.73, and sensitivity of 0.60. Specific connectivity patterns related to PD, motor symptoms improvement after DBS, and therapy responsiveness predictive connectivity profiles were uncovered.

Citace poskytuje Crossref.org

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