-
Something wrong with this record ?
Early social deficits in TgF344-AD rats are accompanied by sex-specific parvalbumin-positive interneuron reduction and altered brain oscillations in the hippocampal CA2
D. Černotová, K. Hrůzová, J. Touš, R. Janča, A. Stuchlík, D. Levčík, J. Svoboda
Language English Country United States
Document type Journal Article
NLK
Directory of Open Access Journals
from 2020
ROAD: Directory of Open Access Scholarly Resources
from 1994
- MeSH
- Alzheimer Disease * physiopathology pathology metabolism MeSH
- CA2 Region, Hippocampal * physiopathology metabolism pathology MeSH
- Interneurons * metabolism pathology MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Parvalbumins * metabolism MeSH
- Sex Characteristics MeSH
- Rats, Inbred F344 MeSH
- Rats, Transgenic MeSH
- Social Behavior * MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Social withdrawal and deficits in social cognition are hallmarks of Alzheimer's disease (AD). While early deficits in social behavior and memory have been documented in mouse AD models, they remain understudied in rat models. Early-stage AD is accompanied by dysfunction of parvalbumin-positive (PV+) interneurons, implicating their potential connection to early symptoms. In this study, we employed a 5-trial social memory task to investigate early deficits in social cognition in 6-month-old TgF344-AD male and female rats. We counted the number of PV+ interneurons and recorded local field potentials during social interactions in the hippocampal CA2 - a region critical for social information processing. Our results show decreased social interest and novelty preference in TgF344-AD male and female rats. However, reduced PV+ interneuron numbers were observed only in female rats and specific to the CA2 area. The electrophysiological recordings revealed reduced theta-gamma phase-amplitude coupling in the CA2 during direct social interactions. We conclude that deficits in social cognition accompany early-stage AD in TgF344-AD rats and are potentially linked to PV+ interneuron and brain oscillatory dysfunction in the CA2 region of the hippocampus.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25015914
- 003
- CZ-PrNML
- 005
- 20250731091343.0
- 007
- ta
- 008
- 250708e20250315xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.nbd.2025.106875 $2 doi
- 035 __
- $a (PubMed)40097074
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Černotová, Daniela $u Laboratory of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic; Third Faculty of Medicine, Charles University, Ruska 87, Prague 100 00, Czech Republic
- 245 10
- $a Early social deficits in TgF344-AD rats are accompanied by sex-specific parvalbumin-positive interneuron reduction and altered brain oscillations in the hippocampal CA2 / $c D. Černotová, K. Hrůzová, J. Touš, R. Janča, A. Stuchlík, D. Levčík, J. Svoboda
- 520 9_
- $a Social withdrawal and deficits in social cognition are hallmarks of Alzheimer's disease (AD). While early deficits in social behavior and memory have been documented in mouse AD models, they remain understudied in rat models. Early-stage AD is accompanied by dysfunction of parvalbumin-positive (PV+) interneurons, implicating their potential connection to early symptoms. In this study, we employed a 5-trial social memory task to investigate early deficits in social cognition in 6-month-old TgF344-AD male and female rats. We counted the number of PV+ interneurons and recorded local field potentials during social interactions in the hippocampal CA2 - a region critical for social information processing. Our results show decreased social interest and novelty preference in TgF344-AD male and female rats. However, reduced PV+ interneuron numbers were observed only in female rats and specific to the CA2 area. The electrophysiological recordings revealed reduced theta-gamma phase-amplitude coupling in the CA2 during direct social interactions. We conclude that deficits in social cognition accompany early-stage AD in TgF344-AD rats and are potentially linked to PV+ interneuron and brain oscillatory dysfunction in the CA2 region of the hippocampus.
- 650 _2
- $a zvířata $7 D000818
- 650 12
- $a interneurony $x metabolismus $x patologie $7 D007395
- 650 12
- $a parvalbuminy $x metabolismus $7 D010320
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a krysa rodu Rattus $7 D051381
- 650 12
- $a Alzheimerova nemoc $x patofyziologie $x patologie $x metabolismus $7 D000544
- 650 12
- $a hipokampální oblast CA2 $x patofyziologie $x metabolismus $x patologie $7 D056651
- 650 12
- $a sociální chování $7 D012919
- 650 _2
- $a potkani inbrední F344 $7 D011916
- 650 _2
- $a potkani transgenní $7 D055647
- 650 _2
- $a pohlavní dimorfismus $7 D012727
- 650 _2
- $a modely nemocí na zvířatech $7 D004195
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Hrůzová, Karolína $u Laboratory of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic; Third Faculty of Medicine, Charles University, Ruska 87, Prague 100 00, Czech Republic
- 700 1_
- $a Touš, Jan $u Laboratory of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic; Faculty of Electrical Engineering, Czech Technical University in Prague, Technicka 2, Prague 160 00, Czech Republic
- 700 1_
- $a Janča, Radek $u Faculty of Electrical Engineering, Czech Technical University in Prague, Technicka 2, Prague 160 00, Czech Republic
- 700 1_
- $a Stuchlík, Aleš $u Laboratory of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic
- 700 1_
- $a Levčík, David $u Laboratory of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic. Electronic address: david.levcik@fgu.cas.cz
- 700 1_
- $a Svoboda, Jan $u Laboratory of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic
- 773 0_
- $w MED00008403 $t Neurobiology of disease $x 1095-953X $g Roč. 208 (20250315), s. 106875
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/40097074 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20250708 $b ABA008
- 991 __
- $a 20250731091338 $b ABA008
- 999 __
- $a ok $b bmc $g 2366628 $s 1253039
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2025 $b 208 $c - $d 106875 $e 20250315 $i 1095-953X $m Neurobiology of disease $n Neurobiol Dis $x MED00008403
- LZP __
- $a Pubmed-20250708
