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Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
A. Nicolas, R. Sherva, B. Grenier-Boley, Y. Kim, M. Kikuchi, J. Timsina, I. de Rojas, MC. Dalmasso, X. Zhou, Y. Le Guen, CE. Arboleda-Bustos, MA. Camargos Bicalho, M. Guerchet, S. van der Lee, M. Goss, A. Castillo, C. Bellenguez, F. Küçükali, CL....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
R01 HL105756
NHLBI NIH HHS - United States
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- Alzheimerova nemoc * genetika epidemiologie mozkomíšní mok MeSH
- apolipoproteiny E genetika MeSH
- běloši * genetika MeSH
- biologické markery mozkomíšní mok MeSH
- celogenomová asociační studie MeSH
- genetická predispozice k nemoci * MeSH
- genetické rizikové skóre MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- multifaktoriální dědičnost * genetika MeSH
- rizikové faktory MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Evropa MeSH
A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.
1st Department of Neurology Medical School Aristotle University of Thessaloniki Thessaloniki Greece
ACE Alzheimer Center Barcelona Universitat Internacional de Catalunya Barcelona Spain
Alzheimer Center Department of Neurology Erasmus MR Rotterdam the Netherlands
Alzheimer Research Center and Memory Clinic Andalusian Institute for Neuroscience Málaga Spain
Alzheimer's Centre Reina Sofia CIEN Foundation ISCIII Madrid Spain
Behavioral Sciences Division National Center for PTSD VA Boston Healthcare System Boston MA USA
Biomedica Research Group Centro de Estudios Clínicos Santiago Chile
BK FOUR Department of Integrative Biological Sciences Chosun University Gwangju Republic of Korea
Bordeaux Population Health Research Center INSERM Bordeaux UMR 1219 Bordeaux France
Bordeaux Population Health Research Center University Bordeaux Inserm Bordeaux France
Boston University and the NHLBI's Framingham Heart Study Boston MA USA
Center for Alzheimer's and Related Dementias NIH Bethesda MD USA
Center for Behavior Genetics of Aging University of California San Diego La Jolla CA USA
Center of Excellence for Stress and Mental Health VA San Diego Healthcare System San Diego CA USA
Centre for Neuropsychiatric Genetics and Genomics School of Medicine Cardiff University Cardiff UK
Centre for Precision Health Edith Cowan University Perth Western Australia Australia
Centro de Biología Molecular Severo Ochoa Madrid Spain
CHU de Bordeaux Pole Santé Publique Bordeaux France
Clinic of Neurology UH Alexandrovska Medical University Sofia Bulgaria
Complex Genetics of Alzheimer's Disease Group VIB Center for Molecular Neurology VIB Antwerp Belgium
Curtin Health Innovation Research Institute Curtin University Perth Western Australia Australia
DataTecnica LLC Washington DC USA
Deaprtment of Clinical and Experimental Sciences University of Brescia Italy Brescia Italy
Department of Biomedical Science Chosun University Gwangju Republic of Korea
Department of Biomedical Sciences University of Antwerp Antwerp Belgium
Department of Biomedical Sciences University of Cagliari Cagliari Italy
Department of Biomedical Surgical and Dental Sciences University of Milan Milan Italy
Department of Biostatistics Boston University School of Public Health Boston MA USA
Department of Biostatistics University of Washington Seattle WA USA
Department of Cardiovascular Sciences University of Leicester Leicester UK
Department of Clinical Biochemistry Copenhagen University Hospital Rigshospitalet Copenhagen Denmark
Department of Clinical Genetics VU University Medical Centre Amsterdam the Netherlands
Department of Clinical Medicine University of Copenhagen Copenhagen Denmark
Department of Clinical Sciences and Community Health University of Milan Milan Italy
Department of Continuity of Care and Frailty ASST Spedali Civili Brescia Brescia Italy
Department of Epidemiology and Biostatistics Case Western Reserve University Cleveland OH USA
Department of Epidemiology Boston University Boston MA USA
Department of Epidemiology ErasmusMC Rotterdam the Netherlands
Department of Genome Sciences University of Washington Seattle WA USA
Department of Geriatric Medicine Oslo University Hospital Oslo Norway
Department of Geriatric Psychiatry University Hospital of Psychiatry Zürich Zurich Switzerland
Department of Hematology and Stem Cell Transplant Vito Fazzi Hospital Lecce Italy
Department of Medical and Molecular Genetics Indiana University Indianapolis IN USA
Department of Medicine Boston University Boston MA USA
Department of Medicine University of Washington Seattle WA USA
Department of Neurology Amitié Hospital Bangui Central African Republic
Department of Neurology and Psychiatry Clínica Alemana Santiago Chile
Department of Neurology Bordeaux University Hospital Bordeaux France
Department of Neurology Boston University Boston MA USA
Department of Neurology Boston University School of Medicine Boston MA USA
Department of Neurology Brazzaville University Hospital Brazzaville Republic of Congo
Department of Neurology Columbia University New York NY USA
Department of Neurology Hospital Universitario Donostia San Sebastian Spain
Department of Neurology UH Alexandrovska Medical University Sofia Bulgaria
Department of Neuroscience Mount Sinai School of Medicine New York NY USA
Department of Neuroscience Rita Levi Montalcini University of Torino Turin Italy
Department of Neuroscience Università Cattolica del Sacro Cuore Rome Italy
Department of Ophthalmology Boston University Boston MA USA
Department of Psychiatry and Psychotherapy University Medical Center Goettingen Goettingen Germany
Department of Psychiatry Boston University Chobanian and Avedisian School of Medicine Boston MA USA
Department of Psychiatry Federal University of Minas Gerais Belo Horizonte Minas Geraes Brazil
Department of Psychiatry Old Age Psychiatry Lausanne University Hospital Lausanne Switzerland
Department of Psychiatry University of California San Diego La Jolla CA USA
Department of Psychiatry Washington University School of Medicine St Louis MO USA
Department of Public Health and Caring Sciences Geriatrics Uppsala University Uppsala Sweden
Department of Public Health and Carins Sciences Geriatrics Uppsala University Uppsala Sweden
Department of Radiology and Biomedical Imaging University of California San Francisco CA USA
Department of Radiology ErasmusMC Rotterdam the Netherlands
Department of Radiology Indiana University Indianapolis IN USA
Department of Surgery Federal University of Minas Gerais Belo Horizonte Minas Geraes Brazil
Depatment of Neurology Columbia University New York NY USA
Division of Aging Brigham and Women's Hospital Harvard Medical School Boston MA USA
Division of Mental Health and Addiction NORMENT Centre Oslo University Hospital Oslo Norway
Dr John T Macdonald Foundation Department of Human Genetics University of Miami Miami FL USA
Faculty of Medicine University of Lisbon Lisbon Portugal
Faculty of Medicine University of Oslo Oslo Norway
Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy
Genetics of Neurodegenerative Diseases Unit IIB Sant Pau Barcelona Spain
Geriatrics Section Clinical Hospital University of Chile Santiago de Chile Chile
German Center for Neurodegenerative Diseases Berlin Germany
German Center for Neurodegenerative Diseases Bonn Germany
German Center for Neurodegenerative Diseases Goettingen Germany
German Center for Neurodegenerative Diseases Magdeburg Germany
German Center for Neurodegenerative Diseases Munich Germany
Geroscience Center for Brain Health and Metabolism Santiago Chile
Gertrude H Sergievsky Center Columbia University New York NY USA
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases San Antonio TX USA
Graduate School of Frontier Science University of Tokyo Tokyo Japan
High Institute of Biotechnology University of Monastir Monastir Tunisia
Hong Kong Center for Neurodegenerative Diseases Hong Kong China
Hôpital Broca Université de Paris EA 4468 APHP Paris France
Hospital Interzonal General de Agudos Eva Perón Buenos Aires Argentina
Institut de Recerca Biomedica de Lleida Lleida Spain
Institut du Cerveau Paris Brain Institute ICM Paris France
Institute for Regenerative Medicine University of Zürich Zurich Switzerland
Institute for Stroke and Dementia Research University Hospital LMU Munich Munich Germany
Institute for Urban Public Health University Hospital Essen University Duisburg Essen Essen Germany
Institute of Biomedicine University of Eastern Finland Kuopio Finland
Institute of Clinical Medicine Neurology University of Eastern Finland Kuopio Finland
Institute of Clinical Medicine University of Oslo Oslo Norway
Institute of Neurology Catholic University of the Sacred Heart Rome Italy
Instituto de Biomedicina de Sevilla IBiS Hospital Universitario Virgen de Valme Sevilla Spain
Instituto de Investigacion Sanitaria 'Hospital la Paz' Madrid Spain
Instituto de Investigación Sanitaria del Principado de Asturias Oviedo Spain
Instituto Nacional de Geriatría Santiago Chile
International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic
Interuniversity Center for Healthy Aging RED21993 Santiago de Chile Chile
IRCCS Fondazione Don Carlo Gnocchi Florence Italy
Krembil Brain Institute University Health Network Toronto Ontario Canada
Laboratorio de Genética Hospital Universitario Central de Asturias Oviedo Spain
Laboratory of Neurogenetics NIH Bethesda MD USA
Laboratory of Neuropsychiatry IRCCS Santa Lucia Foundation Rome Italy
Latin American Institute for Brain Health Universidad Adolfo Ibanez Santiago Chile
Medical Science Department iBiMED Aveiro Portugal
Munich Cluster for Systems Neurology Munich Germany
Neurodegenerative Diseases Unit Fondazione IRCCS Ca' Granda Ospedale Policlinico Milan Italy
NeuroGenomics and Informatics Center Washington University School of Medicine St Louis MO USA
Neurological Tissue Bank Biobanc Hospital Clinic FRCB IDIBAPS Barcelona Spain
Neurology IRCCS San Gerardo dei Tintori Monza and University of Milano Bicocca Milano Italy
Neurology Service Hospital del Salvador Santiago Chile
Neurology Service Marqués de Valdecilla University Hospital Santander Spain
Neurology Unit IRCCS Fondazione Policlinico Universitario A Gemelli Rome Italy
Neuroscience Center Zurich University of Zurich and ETH Zurich Zurich Switzerland
Neurosciences Area Instituto Biogipuzkoa San Sebastian Spain
Niigata University Brain Research Institute Niigata Japan
Norwegian Centre for Ageing and Health Vestfold Hospital Trust Tønsberg Norway
Nuffield Department of Population Health Oxford University Oxford UK
Past Director Dementia Unit University of Parma Parma Italy
Research Center National Center for Geriatrics and Gerontology Obu Japan
Studies in Neuroscience and Complex Systems Unit CONICET HEC UNAJ Buenos Aires Argentina
Studies in Neuroscience and Complex Systems Unit CONICET HEC UNAJ Santiago Chile
The Germans Trias i Pujol Research Institute Badalona Spain
The John P Hussman Institute for Human Genomics University of Miami Miami FL USA
Translational Health Sciences Bristol Medical School University of Bristol Bristol UK
UK Dementia Research Institute Cardiff University Cardiff UK
Unit for Hereditary Dementias Theme Aging Karolinska University Hospital Solna Stockholm Sweden
Unitat de Genètica Molecular Institut de Biomedicina de València CSIC Valencia Spain
Unitat Trastorns Cognitius Hospital Universitari Santa Maria de Lleida Lleida Spain
Universidad Autónoma de Madrid Madrid Spain
Université Paris Saclay CEA Centre National de Recherche en Génomique Humaine Evry France
VA San Diego Healthcare System San Diego CA USA
Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland
Citace poskytuje Crossref.org
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- $a Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations / $c A. Nicolas, R. Sherva, B. Grenier-Boley, Y. Kim, M. Kikuchi, J. Timsina, I. de Rojas, MC. Dalmasso, X. Zhou, Y. Le Guen, CE. Arboleda-Bustos, MA. Camargos Bicalho, M. Guerchet, S. van der Lee, M. Goss, A. Castillo, C. Bellenguez, F. Küçükali, CL. Satizabal, B. Fongang, Q. Yang, O. Peters, A. Schneider, M. Dichgans, D. Rujescu, N. Scherbaum, J. Deckert, S. Riedel-Heller, L. Hausner, L. Molina-Porcel, E. Düzel, T. Grimmer, J. Wiltfang, S. Heilmann-Heimbach, S. Moebus, T. Tegos, N. Scarmeas, O. Dols-Icardo, F. Moreno, J. Pérez-Tur, MJ. Bullido, P. Pastor, R. Sánchez-Valle, V. Álvarez, H. Cao, NY. Ip, AKY. Fu, FCF. Ip, N. Olivar, C. Muchnik, C. Cuesta, L. Campanelli, P. Solis, DG. Politis, S. Kochen, LI. Brusco, M. Boada, P. García-González, R. Puerta, P. Mir, LM. Real, G. Piñol-Ripoll, JM. García-Alberca, JL. Royo, E. Rodriguez-Rodriguez, H. Soininen, S. Heikkinen, A. de Mendonça, S. Mehrabian, L. Traykov, J. Hort, M. Vyhnalek, KL. Rasmussen, JQ. Thomassen, YAL. Pijnenburg, H. Holstege, JC. van Swieten, H. Seelaar, JAHR. Claassen, WJ. Jansen, I. Ramakers, F. Verhey, A. van der Lugt, P. Scheltens, J. Ortega-Rojas, AG. Concha Mera, MF. Mahecha, R. Pardo, G. Arboleda, S. Bahrami, V. Fominykh, G. Selbæk, C. Graff, G. Papenberg, V. Giedraitis, A. Boland, JF. Deleuze, LA. de Marco, EN. de Moraes, B. de Mattos Viana, M. Túlio Gualberto Cintra, T. Juarez-Cedillo, AJ. Griswold, T. Forund, J. Haines, L. Farrer, A. DeStefano, E. Wijsman, R. Mayeux, M. Pericak-Vance, B. Kunkle, A. Goate, GD. Schellenberg, B. Vardarajan, LS. Wang, YY. Leung, CL. Dalgard, G. Nicolas, D. Wallon, C. Dufouil, F. Pasquier, O. Hanon, S. Debette, E. Grünblatt, J. Popp, B. Angel, S. Gloger, MV. Chacon, R. Aranguiz, P. Orellana, A. Slachevsky, C. Gonzalez-Billault, C. Albala, P. Fuentes, P. Sachdev, KA. Mather, RL. Hauger, V. Merritt, M. Panizzon, R. Zhang, JM. Gaziano, R. Ghidoni, D. Galimberti, B. Arosio, P. Mecocci, V. Solfrizzi, L. Parnetti, A. Squassina, L. Tremolizzo, B. Borroni, B. Nacmias, P. Caffarra, D. Seripa, I. Rainero, A. Daniele, F. Piras, EADB, HL. Leonard, JS. Yokoyama, MA. Nalls, A. Miyashita, N. Hara, K. Ozaki, S. Niida, J. Williams, C. Masullo, P. Amouyel, PM. Preux, P. Mbelesso, B. Bandzouzi, A. Saykin, F. Jessen, PG. Kehoe, C. Van Duijn, N. Ben Salem, R. Frikke-Schmidt, L. Cherni, MD. Greicius, M. Tsolaki, P. Sánchez-Juan, MA. Romano Silva, T. Porter, SM. Laws, K. Sleegers, M. Ingelsson, JF. Dartigues, S. Seshadri, G. Rossi, L. Morelli, M. Hiltunen, R. Sims, W. van der Flier, OA. Andreassen, H. Arboleda, C. Cruchaga, V. Escott-Price, A. Ruiz, KH. Lee, T. Ikeuchi, A. Ramirez, J. Gim, M. Logue, JC. Lambert
- 520 9_
- $a A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.
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- 700 1_
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- $a Dols-Icardo, Oriol $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Genetics of Neurodegenerative Diseases Unit IIB Sant Pau, Barcelona, Spain $1 https://orcid.org/0000000326568748
- 700 1_
- $a Moreno, Fermin $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Department of Neurology, Hospital Universitario Donostia, San Sebastian, Spain $u Neurosciences Area, Instituto Biogipuzkoa, San Sebastian, Spain $1 https://orcid.org/0000000152003164
- 700 1_
- $a Pérez-Tur, Jordi $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Unitat de Genètica Molecular, Institut de Biomedicina de València-CSIC, Valencia, Spain $1 https://orcid.org/0000000291111712
- 700 1_
- $a Bullido, María J $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain $u Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain $u Universidad Autónoma de Madrid, Madrid, Spain $1 https://orcid.org/0000000264771117
- 700 1_
- $a Pastor, Pau $u Department of Neurology, Unit of Neurodegenerative Diseases, University Hospital Germans Trias i Pujol, Badalona, Spain $u The Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain $1 https://orcid.org/0000000274938777
- 700 1_
- $a Sánchez-Valle, Raquel $u Alzheimer's Disease and Other Cognitive Disorders Unit, Service of Neurology, Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
- 700 1_
- $a Álvarez, Victoria $u Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain $u Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain $1 https://orcid.org/0000000219162523
- 700 1_
- $a Cao, Han $u Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, China $1 https://orcid.org/0000000199929108
- 700 1_
- $a Ip, Nancy Y $u Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, China $u Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China $u Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research InstituteShenzhen-Hong Kong Institute of Brain Science, Shenzhen, China $1 https://orcid.org/0000000227638907
- 700 1_
- $a Fu, Amy K Y $u Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, China $u Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China $u Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research InstituteShenzhen-Hong Kong Institute of Brain Science, Shenzhen, China
- 700 1_
- $a Ip, Fanny C F $u Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China $u Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research InstituteShenzhen-Hong Kong Institute of Brain Science, Shenzhen, China $1 https://orcid.org/0000000151621761
- 700 1_
- $a Olivar, Natividad $u Center of Neuropsychiatry and Behavior Neurology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina $1 https://orcid.org/0000000345986865
- 700 1_
- $a Muchnik, Carolina $u Center of Neuropsychiatry and Behavior Neurology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina $1 https://orcid.org/0000000215423706
- 700 1_
- $a Cuesta, Carolina $u Hospital Interzonal General de Agudos-Eva Perón, Buenos Aires, Argentina
- 700 1_
- $a Campanelli, Lorenzo $u Laboratory of Brain Aging and Neurodegeneration. Fundacion Instituto Leloir-IIBBA, Buenos Aires, Argentina
- 700 1_
- $a Solis, Patricia $u Studies in Neuroscience and Complex Systems Unit-CONICET-HEC-UNAJ, Buenos Aires, Argentina
- 700 1_
- $a Politis, Daniel Gustavo $u Hospital Interzonal General de Agudos-Eva Perón, Buenos Aires, Argentina
- 700 1_
- $a Kochen, Silvia $u Studies in Neuroscience and Complex Systems Unit-CONICET-HEC-UNAJ, Buenos Aires, Argentina
- 700 1_
- $a Brusco, Luis Ignacio $u Center of Neuropsychiatry and Behavior Neurology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
- 700 1_
- $a Boada, Mercè $u ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $1 https://orcid.org/0000000326173009
- 700 1_
- $a García-González, Pablo $u ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain $1 https://orcid.org/0000000301255403
- 700 1_
- $a Puerta, Raquel $u ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain $1 https://orcid.org/0000000211915893
- 700 1_
- $a Mir, Pablo $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Instituto de Biomedicina de Sevilla (IBiS)Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain $1 https://orcid.org/000000031656302X
- 700 1_
- $a Real, Luis M $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen de Valme, Sevilla, Spain $u Depatamento de Bioquímica Médica, Biología Molecular e Inmunología, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain $1 https://orcid.org/0000000349327429
- 700 1_
- $a Piñol-Ripoll, Gerard $u Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain $u Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain
- 700 1_
- $a García-Alberca, Jose María $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Alzheimer Research Center and Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain $1 https://orcid.org/0000000329516644
- 700 1_
- $a Royo, Jose Luís $u Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain
- 700 1_
- $a Rodriguez-Rodriguez, Eloy $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain $1 https://orcid.org/000000017742677X
- 700 1_
- $a Soininen, Hilkka $u Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland $1 https://orcid.org/0000000227859937
- 700 1_
- $a Heikkinen, Sami $u Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland $1 https://orcid.org/0000000260832402
- 700 1_
- $a de Mendonça, Alexandre $u Faculty of Medicine, University of Lisbon, Lisbon, Portugal
- 700 1_
- $a Mehrabian, Shima $u Clinic of Neurology, UH Alexandrovska, Medical University, Sofia, Bulgaria
- 700 1_
- $a Traykov, Latchezar $u Department of Neurology, UH Alexandrovska, Medical University, Sofia, Bulgaria
- 700 1_
- $a Hort, Jakub $u Department of Neurology, Memory Clinic, Charles University, Second Faculty of Medicine and Motol University Hospital, Brno, Czech Republic $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic $1 https://orcid.org/0000000210803726
- 700 1_
- $a Vyhnalek, Martin $u Department of Neurology, Memory Clinic, Charles University, Second Faculty of Medicine and Motol University Hospital, Brno, Czech Republic $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
- 700 1_
- $a Rasmussen, Katrine Laura $u Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark $u Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
- 700 1_
- $a Thomassen, Jesper Qvist $u Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark $1 https://orcid.org/0000000334849531
- 700 1_
- $a Pijnenburg, Yolande A L $u Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
- 700 1_
- $a Holstege, Henne $u Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $u Department of Clinical Genetics, VU University Medical Centre, Amsterdam, the Netherlands $1 https://orcid.org/0000000276883087
- 700 1_
- $a van Swieten, John C $u Alzheimer Center, Department of Neurology, Erasmus MR, Rotterdam, the Netherlands
- 700 1_
- $a Seelaar, Harro $u Alzheimer Center, Department of Neurology, Erasmus MR, Rotterdam, the Netherlands $1 https://orcid.org/0000000319897527
- 700 1_
- $a Claassen, Jurgen A H R $u Department of Geriatrics, Radboud University Medical Center, Research Institute for Medical Innovation, Rotterdam, the Netherlands $u Department of Cardiovascular Sciences, University of Leicester, Leicester, UK $1 https://orcid.org/0000000217788151
- 700 1_
- $a Jansen, Willemijn J $u Department of Psychiatry and Neuropsychology, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands
- 700 1_
- $a Ramakers, Inez $u Department of Psychiatry and Neuropsychology, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands
- 700 1_
- $a Verhey, Frans $u Department of Psychiatry and Neuropsychology, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands
- 700 1_
- $a van der Lugt, Aad $u Department of Radiology, ErasmusMC, Rotterdam, the Netherlands
- 700 1_
- $a Scheltens, Philip $u Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $1 https://orcid.org/0000000210466408 $7 xx0207285
- 700 1_
- $a Ortega-Rojas, Jenny $u Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia
- 700 1_
- $a Concha Mera, Ana Gabriela $u Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia
- 700 1_
- $a Mahecha, Maria F $u Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia $1 https://orcid.org/0000000223065216
- 700 1_
- $a Pardo, Rodrigo $u Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia
- 700 1_
- $a Arboleda, Gonzalo $u Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia
- 700 1_
- $a Bahrami, Shahram $u Division of Mental Health and Addiction, NORMENT Centre, Oslo University Hospital, Oslo, Norway $u Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- 700 1_
- $a Fominykh, Vera $u Division of Mental Health and Addiction, NORMENT Centre, Oslo University Hospital, Oslo, Norway $u Institute of Clinical Medicine, University of Oslo, Oslo, Norway $1 https://orcid.org/0000000154902390
- 700 1_
- $a Selbæk, Geir $u Norwegian Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway $u Faculty of Medicine, University of Oslo, Oslo, Norway $u Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway $1 https://orcid.org/0000000165118219
- 700 1_
- $a Graff, Caroline $u Unit for Hereditary Dementias, Theme Aging, Karolinska University Hospital-Solna, Stockholm, Sweden
- 700 1_
- $a Papenberg, Goran $u Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden
- 700 1_
- $a Giedraitis, Vilmantas $u Department of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden $1 https://orcid.org/0000000334232021
- 700 1_
- $a Boland, Anne $u Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), Evry, France $1 https://orcid.org/0000000187895676
- 700 1_
- $a Deleuze, Jean-François $u Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), Evry, France
- 700 1_
- $a de Marco, Luiz Armando $u National Institute of Science and Technology (INCT) Neurotec R, Federal University of Minas Geraes Belo Horizonte, Minas Geraes, Brazil $u Department of Surgery, Federal University of Minas Gerais (UFMG) Belo Horizonte, Minas Geraes, Brazil
- 700 1_
- $a de Moraes, Edgar Nunes $u Department of Clinical Medicine, Federal University of Minas Gerais (UFMG) Belo Horizonte, Minas Geraes, Brazil $u Geriatrics Service of the University Hospital, Federal University of Minas Gerais Belo Horizonte, Minas Geraes, Brazil
- 700 1_
- $a de Mattos Viana, Bernardo $u National Institute of Science and Technology (INCT) Neurotec R, Federal University of Minas Geraes Belo Horizonte, Minas Geraes, Brazil $u Department of Psychiatry, Federal University of Minas Gerais (UFMG) Belo Horizonte, Minas Geraes, Brazil $u Psychiatry Service of the University Hospital, Federal University of Minas Gerais, Belo Horizonte, Minas Geraes, Brazil
- 700 1_
- $a Túlio Gualberto Cintra, Marco $u Department of Clinical Medicine, Federal University of Minas Gerais (UFMG) Belo Horizonte, Minas Geraes, Brazil $u Geriatrics Service of the University Hospital, Federal University of Minas Gerais Belo Horizonte, Minas Geraes, Brazil
- 700 1_
- $a Juarez-Cedillo, Teresa $u Unidad de Investigación Epidemiológica y en Servicios de Salud, Área Envejecimiento, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico $1 https://orcid.org/0000000294423471
- 700 1_
- $a Griswold, Anthony J $u The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA
- 700 1_
- $a Forund, Tatiana $u Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA
- 700 1_
- $a Haines, Jonathan $u Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
- 700 1_
- $a Farrer, Lindsay $u Department of Medicine (Biomedical Genetics), Boston University, Boston, MA, USA $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA $u Department of Epidemiology, Boston University, Boston, MA, USA $u Department of Neurology, Boston University, Boston, MA, USA $u Department of Ophthalmology, Boston University, Boston, MA, USA $1 https://orcid.org/0000000155334225
- 700 1_
- $a DeStefano, Anita $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
- 700 1_
- $a Wijsman, Ellen $u Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA $u Department of Biostatistics, University of Washington, Seattle, WA, USA $u Department of Genome Sciences, University of Washington, Seattle, WA, USA $1 https://orcid.org/0000000227256669
- 700 1_
- $a Mayeux, Richard $u Department of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA $u Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA $1 https://orcid.org/0000000165199696
- 700 1_
- $a Pericak-Vance, Margaret $u The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA $u Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA $1 https://orcid.org/0000000172838804 $7 uk2007404221
- 700 1_
- $a Kunkle, Brian $u The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA
- 700 1_
- $a Goate, Alison $u Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA $1 https://orcid.org/0000000205762472
- 700 1_
- $a Schellenberg, Gerard D $u Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
- 700 1_
- $a Vardarajan, Badri $u Department of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA $u Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA $u Department of Neurology, Columbia University, New York, NY, USA $1 https://orcid.org/0000000255604085
- 700 1_
- $a Wang, Li-San $u Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
- 700 1_
- $a Leung, Yuk Yee $u Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA $1 https://orcid.org/0000000230475440
- 700 1_
- $a Dalgard, Clifton L $u Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA $u Center for Military Precision Health, The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA $1 https://orcid.org/0000000320258239
- 700 1_
- $a Nicolas, Gael $u Department of Genetics and CNR-MAJ, Université Rouen Normandie, Normandie Université, Inserm U1245 and CHU Rouen, Rouen, France $1 https://orcid.org/0000000193917800
- 700 1_
- $a Wallon, David $u Department of Genetics and CNR-MAJ, Université Rouen Normandie, Normandie Université, Inserm U1245 and CHU Rouen, Rouen, France $1 https://orcid.org/0000000226347198
- 700 1_
- $a Dufouil, Carole $u Bordeaux Population Health Research Center, Inserm, UMR 1219, Université Bordeaux, ISPED, CIC 1401-EC, Université Bordeaux, Bordeaux, France $u CHU de Bordeaux, Pole Santé Publique, Bordeaux, France $1 https://orcid.org/0000000324424476
- 700 1_
- $a Pasquier, Florence $u CHU Clinical and Research Memory Research Centre (CMRR) of Distalz Lille France, Université Lille Inserm 1171, Paris, France
- 700 1_
- $a Hanon, Olivier $u Hôpital Broca, Université de Paris, EA 4468, APHP, Paris, France
- 700 1_
- $a Debette, Stéphanie $u Bordeaux Population Health Research Center, University Bordeaux, Inserm, Bordeaux, France $u Department of Neurology, Bordeaux University Hospital, Bordeaux, France $1 https://orcid.org/0000000186757968
- 700 1_
- $a Grünblatt, Edna $u Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland $u Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland $u Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland $1 https://orcid.org/0000000185057265
- 700 1_
- $a Popp, Julius $u Department of Psychiatry, Old Age Psychiatry, Lausanne University Hospital, Lausanne, Switzerland $u Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zurich, Switzerland $u Institute for Regenerative Medicine, University of Zürich, Zurich, Switzerland
- 700 1_
- $a Angel, Bárbara $u Public Health Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago de Chile, Chile $u Interuniversity Center for Healthy Aging RED21993, Santiago de Chile, Chile $1 https://orcid.org/0000000187735904
- 700 1_
- $a Gloger, Sergio $u Biomedica Research Group, Centro de Estudios Clínicos, Santiago, Chile $u Departamento de Psiquiatría y Salud Mental, Campus Oriente, Facultad de MedicinaUniversidad de Chile, Santiago, Chile $1 https://orcid.org/0000000286741306
- 700 1_
- $a Chacon, Maria Victoria $u Biomedica Research Group, Centro de Estudios Clínicos, Santiago, Chile
- 700 1_
- $a Aranguiz, Rafael $u Biomedica Research Group, Centro de Estudios Clínicos, Santiago, Chile $u Instituto Nacional de Geriatría, Santiago, Chile $u Department of Neurology and Psychiatry, Clínica Alemana, Santiago, Chile
- 700 1_
- $a Orellana, Paulina $u Geroscience Center for Brain Health and Metabolism, Santiago, Chile $u Latin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile $1 https://orcid.org/0000000187527750
- 700 1_
- $a Slachevsky, Andrea $u Geroscience Center for Brain Health and Metabolism, Santiago, Chile $u Memory and Neuropsychiatric Center (CMYN) Neurology Department, Hospital del Salvador y Facultad de Medicina, Universidad de Chile, Santiago, Chile
- 700 1_
- $a Gonzalez-Billault, Christian $u Public Health Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago de Chile, Chile $u Geroscience Center for Brain Health and Metabolism, Santiago, Chile $1 https://orcid.org/0000000303351482
- 700 1_
- $a Albala, Cecilia $u Public Health Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago de Chile, Chile $u Interuniversity Center for Healthy Aging RED21993, Santiago de Chile, Chile $1 https://orcid.org/000000026135334X
- 700 1_
- $a Fuentes, Patricio $u Geriatrics Section Clinical Hospital University of Chile, Santiago de Chile, Chile $u Neurology Service Hospital del Salvador, Santiago, Chile
- 700 1_
- $a Sachdev, Perminder $u Centre for Healthy Brain Ageing School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia $1 https://orcid.org/0000000295953220 $7 xx0192334
- 700 1_
- $a Mather, Karen A $u Centre for Healthy Brain Ageing School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia $1 https://orcid.org/0000000341438941
- 700 1_
- $a Hauger, Richard L $u Center of Excellence for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, CA, USA $u Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA, USA $1 https://orcid.org/0000000315091868
- 700 1_
- $a Merritt, Victoria $u VA San Diego Healthcare System, San Diego, CA, USA $u Department of Psychiatry, University of California San Diego, La Jolla, CA, USA $u Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA $1 https://orcid.org/0000000156834168
- 700 1_
- $a Panizzon, Matthew $u Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA, USA $u Department of Psychiatry, University of California San Diego, La Jolla, CA, USA $u Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA
- 700 1_
- $a Zhang, Rui $u Behavioral Sciences Division, National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA
- 700 1_
- $a Gaziano, J Michael $u Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA $u Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
- 700 1_
- $a Ghidoni, Roberta $u Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy $1 https://orcid.org/0000000276911957
- 700 1_
- $a Galimberti, Daniela $u Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy $u Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy $1 https://orcid.org/0000000292845953
- 700 1_
- $a Arosio, Beatrice $u Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy $1 https://orcid.org/0000000206153580
- 700 1_
- $a Mecocci, Patrizia $u Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy $u Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden $1 https://orcid.org/0000000307295246
- 700 1_
- $a Solfrizzi, Vincenzo $u Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unit, University of Bari A. Moro, Bari, Italy $1 https://orcid.org/0000000285240315
- 700 1_
- $a Parnetti, Lucilla $u Centre for Memory Disturbances, Laboratory of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy $1 https://orcid.org/0000000157223967
- 700 1_
- $a Squassina, Alessio $u Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy $1 https://orcid.org/0000000174157607
- 700 1_
- $a Tremolizzo, Lucio $u Neurology, IRCCS San Gerardo dei Tintori, Monza and University of Milano-Bicocca, Milano, Italy
- 700 1_
- $a Borroni, Barbara $u Deaprtment of Clinical and Experimental Sciences, University of Brescia Italy, Brescia, Italy $u Department of Continuity of Care and Frailty, ASST Spedali Civili Brescia, Brescia, Italy
- 700 1_
- $a Nacmias, Benedetta $u Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy $u IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy $1 https://orcid.org/0000000193389040
- 700 1_
- $a Caffarra, Paolo $u Past Director Dementia Unit University of Parma, Parma, Italy
- 700 1_
- $a Seripa, Davide $u Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy
- 700 1_
- $a Rainero, Innocenzo $u Department of Neuroscience Rita Levi Montalcini, University of Torino, Turin, Italy
- 700 1_
- $a Daniele, Antonio $u Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy $u Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy
- 700 1_
- $a Piras, Fabrizio $u Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy
- 700 1_
- $a Leonard, Hampton L $u Center for Alzheimer's and Related Dementias, NIH, Bethesda, MD, USA $u DataTecnica LLC, Washington, DC, USA
- 700 1_
- $a Yokoyama, Jenifer S $u DataTecnica LLC, Washington, DC, USA $u Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA $u Pharmaceutical Sciences and Pharmacogenomics Graduate Program, University of California, San Francisco, CA, USA $u Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA $1 https://orcid.org/0000000172742634
- 700 1_
- $a Nalls, Mike A $u Center for Alzheimer's and Related Dementias, NIH, Bethesda, MD, USA $u DataTecnica LLC, Washington, DC, USA $u Laboratory of Neurogenetics, NIH, Bethesda, MD, USA $1 https://orcid.org/0000000303194325
- 700 1_
- $a Miyashita, Akinori $u Niigata University, Brain Research Institute, Niigata, Japan $1 https://orcid.org/0000000325089649
- 700 1_
- $a Hara, Norikazu $u Niigata University, Brain Research Institute, Niigata, Japan $1 https://orcid.org/0000000185253469
- 700 1_
- $a Ozaki, Kouichi $u Research Center, National Center for Geriatrics and Gerontology, Obu, Japan $1 https://orcid.org/0000000300281570
- 700 1_
- $a Niida, Shumpei $u Research Center, National Center for Geriatrics and Gerontology, Obu, Japan
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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