V procese výskumu a vývoje liečiva má svoje nezastupiteľné miesto aj sledovanie stability liečiva, resp. lieku. V tomto príspevku je to potenciálne liečivo H+B, chemicky N-[2-(2-heptyloxyfenylkarbamoyloxy)-etyl]-N-benzylpipendiniumchlorid, s výrazným antiarytmickým a tiež lokálne anestetickým účinkom. Sledovala sa stabilita potenciálneho liečiva H+B v roztoku bez a v prítomnosti polyolov za účelom formulácie injekčného roztoku pre intramuskulámu aplikáciu.

In the process of drug research and development an irreplaceable stage is the examination of stability of the drug or the pharmaceutical preparation. The present paper examines the potential drug H+B, chemically N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]-N-benzylpiperidinium chloride, an agent with a marked anti-arrhytmic and local anaesthetic effect. Stability tests aim to examine the effects of polyols on the stability of the potential drug H+B from the standpoint of the formulation of injection solution for intramuscular administration.

Univ Kom Farm fakulta Katedra galenickej farmácie Bratislava

Studies of local anaesthetics. 141. Effects of polyols on the stability of the solution of N-[2-(2-heptyloxyfenylkarbamyoloxy)-etyl]-N-benzylpiperidiniumchloridu (H+B)

Štúdium lokálnych anestetík. 141. Stabilita roztokov N-[2-(2-heptyloxyfenylkarbamoyloxy)-etyl]-N-benzylpiperidiniumchloridu (H+B) = Studies of local anaesthetics. 141. Effects of polyols on the stability of the solution of N-[2-(2-heptyloxyfenylkarbamyoloxy)-etyl]-N-benzylpiperidiniumchloridu (H+B) /

Studies of local anaesthetics. 141. Effects of polyols on the stability of the solution of N-[2-(2-heptyloxyfenylkarbamyoloxy)-etyl]-N-benzylpiperidiniumchloridu (H+B) /

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