Involvement of arachidonic acid and its metabolites in the inhibitory effect of beta-adrenoceptor blocking drugs on blood platelets
Jazyk angličtina Země Švýcarsko Médium print
Typ dokumentu časopisecké články
- MeSH
- beta blokátory farmakologie MeSH
- inhibitory agregace trombocytů farmakologie MeSH
- krysa rodu Rattus MeSH
- kyselina arachidonová krev fyziologie MeSH
- malondialdehyd krev MeSH
- techniky in vitro MeSH
- trombin farmakologie MeSH
- trombocyty účinky léků metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- beta blokátory MeSH
- inhibitory agregace trombocytů MeSH
- kyselina arachidonová MeSH
- malondialdehyd MeSH
- trombin MeSH
Propranolol (PRO), alprenolol (ALP), metipranolol (MET) and oxprenolol (OXP) inhibited arachidonic acid (AA) liberation from membrane phospholipids, malondialdehyde (MDA) formation and thromboxane B2 (TXB2) production in stimulated platelets. The inhibition was dose-dependent and with slight variations followed the rank order of potency: PRO greater than or equal to ALP greater than or equal to MET greater than or equal to OXP. Atenolol (ATE) was without any inhibitory effect. Inhibition of the arachidonic acid pathway in stimulated platelets may significantly contribute to the antiaggregatory effect of beta-adrenoceptor blocking drugs.
Citace poskytuje Crossref.org
