Effects of supercypermethrin, a synthetic developmental pyrethroid, on four biological test systems
Language English Country Netherlands Media print
Document type Journal Article
PubMed
1381478
DOI
10.1016/0165-1218(92)90044-z
PII: 0165-1218(92)90044-Z
Knihovny.cz E-resources
- MeSH
- Sex Chromosome Aberrations * MeSH
- Biotransformation MeSH
- Chromosome Aberrations * MeSH
- Chromosome Deletion MeSH
- Drosophila melanogaster drug effects genetics MeSH
- Gene Conversion drug effects MeSH
- Rats, Inbred Strains MeSH
- Microsomes, Liver metabolism MeSH
- Rats MeSH
- Mutagens pharmacology MeSH
- Pyrethrins pharmacology toxicity MeSH
- Plants drug effects genetics MeSH
- Saccharomyces cerevisiae drug effects genetics MeSH
- Salmonella typhimurium drug effects genetics MeSH
- Mutagenicity Tests MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- cypermethrin MeSH Browser
- Mutagens MeSH
- Pyrethrins MeSH
The genotoxic potential of the insecticide supercypermethrin, a second-generation pyrethroid, was studied on four different test systems. It was non-mutagenic to Salmonella typhimurium strains TA1535, TA100, TA1538, TA98 and TA97 in the presence and absence of S9 mixture. It induced gene conversion at the tryptophan locus and induced point mutations at the isoleucine locus in Saccharomyces cerevisiae cells. A slight increase in the frequency of aberrant anaphases and telophases in root tips of Hordeum vulgare and Vicia faba was observed, but no genotoxic effects were detected in Drosophila melanogaster.
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