The hypertriglyceridemic rat as a genetic model of hypertension and diabetes
Language English Country Netherlands Media print
Document type Journal Article
PubMed
1513201
DOI
10.1016/0024-3205(92)90482-5
PII: 0024-3205(92)90482-5
Knihovny.cz E-resources
- MeSH
- Epinephrine blood MeSH
- Diabetes Mellitus genetics MeSH
- Glucose Tolerance Test MeSH
- Hyperlipoproteinemia Type IV blood genetics physiopathology MeSH
- Hypertension genetics MeSH
- Rats, Inbred Strains MeSH
- Insulin blood MeSH
- Blood Glucose analysis MeSH
- Blood Pressure MeSH
- Rats MeSH
- Models, Genetic MeSH
- Disease Models, Animal * MeSH
- Norepinephrine blood MeSH
- Body Weight MeSH
- Triglycerides blood MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Epinephrine MeSH
- Insulin MeSH
- Blood Glucose MeSH
- Norepinephrine MeSH
- Triglycerides MeSH
Hypertriglyceridemia was demonstrated in untreated hypertensive patients as well as in animals with genetic and experimental hypertension. The main purpose of the present study was to evaluate the possibility to use the hereditary hypertriglyceridemic (HTG) nonobese rats in hypertensive research. Direct measurement of blood pressure demonstrated significantly higher systolic, diastolic and mean arterial pressures in HTG rats in comparison with control Wistar rats. There was significant positive correlation between blood pressure and plasma triglyceride concentration (r = 0.585, n = 40, p less than 0.001). In addition, there were significantly increased plasma norepinephrine and epinephrine concentrations in HTG rats, suggesting that the stimulation of sympathetic nervous system could be one of the pathogenetic mechanisms involved in the increase of blood pressure of HTG rats.
References provided by Crossref.org
Research on Experimental Hypertension in Prague (1966-2009)
Metabolic Syndrome in Hypertriglyceridemic Rats: Effects of Antioxidants
