The hypertriglyceridemic rat as a genetic model of hypertension and diabetes
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články
PubMed
1513201
DOI
10.1016/0024-3205(92)90482-5
PII: 0024-3205(92)90482-5
Knihovny.cz E-zdroje
- MeSH
- adrenalin krev MeSH
- diabetes mellitus genetika MeSH
- glukózový toleranční test MeSH
- hyperlipoproteinemie typ IV krev genetika patofyziologie MeSH
- hypertenze genetika MeSH
- inbrední kmeny potkanů MeSH
- inzulin krev MeSH
- krevní glukóza analýza MeSH
- krevní tlak MeSH
- krysa rodu Rattus MeSH
- modely genetické MeSH
- modely nemocí na zvířatech * MeSH
- noradrenalin krev MeSH
- tělesná hmotnost MeSH
- triglyceridy krev MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adrenalin MeSH
- inzulin MeSH
- krevní glukóza MeSH
- noradrenalin MeSH
- triglyceridy MeSH
Hypertriglyceridemia was demonstrated in untreated hypertensive patients as well as in animals with genetic and experimental hypertension. The main purpose of the present study was to evaluate the possibility to use the hereditary hypertriglyceridemic (HTG) nonobese rats in hypertensive research. Direct measurement of blood pressure demonstrated significantly higher systolic, diastolic and mean arterial pressures in HTG rats in comparison with control Wistar rats. There was significant positive correlation between blood pressure and plasma triglyceride concentration (r = 0.585, n = 40, p less than 0.001). In addition, there were significantly increased plasma norepinephrine and epinephrine concentrations in HTG rats, suggesting that the stimulation of sympathetic nervous system could be one of the pathogenetic mechanisms involved in the increase of blood pressure of HTG rats.
Citace poskytuje Crossref.org
Research on Experimental Hypertension in Prague (1966-2009)
Metabolic Syndrome in Hypertriglyceridemic Rats: Effects of Antioxidants
