Hepcidin in newly diagnosed inflammatory bowel disease in children
Jazyk angličtina Země Austrálie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
29923651
DOI
10.1111/jpc.14093
Knihovny.cz E-zdroje
- Klíčová slova
- Crohn's disease, anaemia, children, hepcidin, inflammatory bowel disease, ulcerative colitis,
- MeSH
- antiinfekční látky krev MeSH
- C-reaktivní protein analýza MeSH
- dítě MeSH
- feces chemie MeSH
- ferritiny krev MeSH
- hepcidiny krev MeSH
- idiopatické střevní záněty diagnóza MeSH
- leukocytární L1-antigenní komplex krev MeSH
- lidé MeSH
- mladiství MeSH
- průřezové studie MeSH
- železo krev MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antiinfekční látky MeSH
- C-reaktivní protein MeSH
- ferritiny MeSH
- hepcidiny MeSH
- leukocytární L1-antigenní komplex MeSH
- železo MeSH
AIM: Hepcidin is a central regulator of iron homeostasis. Its production is also influenced by systemic inflammation. The aims of this study were to compare hepcidin levels in paediatric patients newly diagnosed with Crohn's disease (CD) and ulcerative colitis (UC) and to determine the association of hepcidin levels with laboratory and clinical parameters of inflammatory bowel disease (IBD) activity. METHODS: Children with newly diagnosed IBD between January 2012 and September 2016 were enrolled in this comparative cross-sectional study. We analysed levels of serum hepcidin, C-reactive protein, iron, ferritin, soluble transferrin receptors, blood count and faecal calprotectin in all subjects. Serum hepcidin levels were measured by reverse-phase liquid chromatography. The Paediatric Crohn's Disease Activity Index was used to evaluate CD in children, and Paediatric Ulcerative Colitis Activity Index was used for the assessment of UC disease activity. RESULTS: Subjects with CD (n = 53) had significantly higher serum hepcidin levels compared with subjects with UC (n = 23) - 22.6 ng/mL (range 8.5-65.0) versus 6.5 ng/mL (range 2.4-25.8) (P < 0.05). Hepcidin was independently associated with ferritin levels in all IBD patients (P < 0.05). Moreover, there was a significant positive correlation between hepcidin and platelet count (P < 0.05) in children with CD and a negative correlation between hepcidin and faecal calprotectin (P < 0.05) in children with UC. CONCLUSION: Different hepcidin levels between children with newly diagnosed CD and UC suggest the distinct contribution of iron deficiency and/or systemic inflammation to anaemia and may help clinicians choose the best anti-anaemic treatment.
Citace poskytuje Crossref.org
Importance of Hepcidin in the Etiopathogenesis of Anemia in Inflammatory Bowel Disease
