Effect of dimethyl sulfoxide on lysine production by a mutant of Bacillus subtilis with homoserine dehydrogenase activity
Language English Country United States Media print
Document type Journal Article
PubMed
1821870
DOI
10.1007/bf02884064
Knihovny.cz E-resources
- MeSH
- Bacillus subtilis drug effects genetics metabolism MeSH
- Cysteine analogs & derivatives pharmacology MeSH
- Dimethyl Sulfoxide pharmacology MeSH
- Homoserine Dehydrogenase metabolism MeSH
- Lysine biosynthesis MeSH
- Mutation MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cysteine MeSH
- Dimethyl Sulfoxide MeSH
- Homoserine Dehydrogenase MeSH
- Lysine MeSH
- S-2-aminoethyl cysteine MeSH Browser
Some Bacillus subtilis mutants with different levels of homoserine dehydrogenase were described. Strains that do not accumulate methionine have a high homoserine dehydrogenase activity. Low activity was detected in mutants where cell growth was completely inhibited by 0.7 mmol/L methionine. A low concentration of dimethyl sulfoxide had a stimulatory effect on lysine production by the methionine-sensitive mutant of Bacillus subtilis.
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