Role of intron 5 C/T polymorphism of the calcium sensing receptor gene in the regulation of the serum FSH and LH in post-menopausal women
Jazyk angličtina Země Itálie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
16218047
DOI
10.1007/bf03347263
PII: 2648
Knihovny.cz E-zdroje
- MeSH
- alely MeSH
- dospělí MeSH
- folikuly stimulující hormon krev MeSH
- genotyp MeSH
- introny * MeSH
- lidé MeSH
- luteinizační hormon krev MeSH
- polymorfismus genetický * MeSH
- postmenopauza * MeSH
- průřezové studie MeSH
- receptory "calcium-sensing" genetika metabolismus MeSH
- statistika jako téma MeSH
- vápník metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- folikuly stimulující hormon MeSH
- luteinizační hormon MeSH
- receptory "calcium-sensing" MeSH
- vápník MeSH
OBJECTIVE: High extracellular calcium concentration (Cao(2+)) acts to inhibit calcium sensing receptor (CaR) signalling on cellular surfaces in parathyroid glands. This receptor is, however, also expressed on the membranes of some non-calciotropic endocrine cells, including pituitary-derived cells. The aim of our study was to analyse relationships between the CaR gene and the circulating FSH and LH in normal post-menopausal women. METHODS: A total of 95 untreated euparathyroid post-menopausal women were investigated in the study. The serum FSH and LH levels were evaluated in relationship to allele combinations of the CaR gene (C/T polymorphism in the intron 5 and A986S polymorphism in exon 7), using an analysis of co-variance (ANCOVA) model. RESULTS: Distribution of TT, TC and CC allele combinations (intron 5 C/T polymorphism) was 51, 43 and 6 %, respectively. Higher serum FSH and LH levels were found in carriers of C allele than in women without this allele (p < 0.002 and p < 0.03, respectively). No correlations were found between A986S polymorphism and serum FSH and LH levels. CONCLUSIONS: Serum FSH and LH levels are associated with intron 5 C/T (but not A986S) polymorphism of the CaR gene in untreated post-menopausal women. The physiological role of the CaR gene in the regulation of the gonadotropic function needs to be further investigated.
Zobrazit více v PubMed
Eur J Endocrinol. 2001 Oct;145(4):421-7 PubMed
J Biol Chem. 1996 Aug 9;271(32):19537-45 PubMed
J Physiol. 2004 Mar 16;555(Pt 3):769-82 PubMed
Biochem Biophys Res Commun. 1997 Sep 29;238(3):866-73 PubMed
Horm Metab Res. 2002 Mar;34(3):127-31 PubMed
Eur J Endocrinol. 2001 Mar;144(3):257-61 PubMed
Lancet. 1999 Jan 9;353(9147):112-5 PubMed
Clin Endocrinol (Oxf). 2001 Sep;55(3):373-9 PubMed
Nucleic Acids Res. 1988 Feb 11;16(3):1215 PubMed
J Clin Endocrinol Metab. 1984 Jul;59(1):56-61 PubMed
Bone. 2002 Jun;30(6):849-52 PubMed
J Endocrinol Invest. 2004 May;27(5):442-4 PubMed
Eur J Endocrinol. 2003 Jun;148(6):603-7 PubMed
Scand J Clin Lab Invest Suppl. 1997;227:122-5 PubMed
J Endocrinol Invest. 2002 Jul-Aug;25(7):614-9 PubMed
Mol Endocrinol. 1996 May;10(5):555-65 PubMed
J Bone Miner Res. 2003 Nov;18(11):1921-31 PubMed
Cell Calcium. 1996 Jan;19(1):43-57 PubMed
Physiol Rev. 2001 Jan;81(1):239-297 PubMed
Endocrinology. 1984 Oct;115(4):1380-5 PubMed
Nephron. 2000 Aug;85(4):317-23 PubMed
Horm Metab Res. 1996 Oct;28(10):541-4 PubMed
