Cholesterol esterification rates in very low density lipoprotein- and low density lipoprotein-depleted plasma. Relation to high density lipoprotein subspecies, sex, hyperlipidemia, and coronary artery disease
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
1988005
DOI
10.1161/01.atv.11.1.64
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Electrophoresis, Polyacrylamide Gel MeSH
- Esterification MeSH
- Hyperlipidemias blood MeSH
- Hyperlipoproteinemia Type II blood MeSH
- Hypertriglyceridemia blood MeSH
- Coronary Disease blood MeSH
- Cholesterol, LDL blood metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Reference Values MeSH
- Risk Factors MeSH
- Aged MeSH
- Sex Factors MeSH
- Triglycerides blood metabolism MeSH
- Cholesterol, VLDL blood metabolism MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cholesterol, LDL MeSH
- Triglycerides MeSH
- Cholesterol, VLDL MeSH
The fractional rate of cholesterol esterification in very low density lipoprotein- and low density lipoprotein-depleted plasma (FERHDL) was studied in normolipidemic subjects and in individuals with hyperlipidemia and proven coronary artery disease (CAD). The FERHDL was significantly higher than the FER in whole plasma and was significantly higher in normal men than in normal women. In addition, men and women with primary hyperlipidemia had significantly higher FERHDL values relative to their sex-matched controls. The most significant increases in FERHDL values, however, were observed in individuals with CAD. In all patient groups, FERHDL was positively correlated with plasma triglyceride concentration. In addition, FERHDL was negatively related to plasma high density lipoprotein (HDL) cholesterol concentration in all groups except in men with CAD and in normolipidemic women. The gradient gel electrophoretic pattern of HDL from individuals with either low or high FERHDL values indicated an inverse relation between this activity and the relative amount of HDL2b particles. FERHDL likely reflects the metabolic properties of the heterogeneous population of HDL particles in the plasma and may be a function of the relative content of larger and smaller HDL particles. It appears to be a sensitive and reliable functional measure of the particle size distribution in the HDL pool and one of potential clinical value in the assessment of risk for CAD.
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