Phenylmethylsulfonyl fluoride protects L-lysine transport in Schizosaccharomyces pombe against inactivation by ammonium ions
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
2110481
DOI
10.1016/0005-2736(90)90129-c
PII: 0005-2736(90)90129-C
Knihovny.cz E-zdroje
- MeSH
- amoniak farmakologie MeSH
- biologický transport účinky léků MeSH
- časové faktory MeSH
- fenylmethylsulfonylfluorid farmakologie MeSH
- lysin metabolismus MeSH
- mutace MeSH
- Saccharomyces cerevisiae účinky léků genetika metabolismus MeSH
- Saccharomycetales metabolismus MeSH
- Schizosaccharomyces účinky léků metabolismus MeSH
- sulfony farmakologie MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- amoniak MeSH
- fenylmethylsulfonylfluorid MeSH
- lysin MeSH
- sulfony MeSH
Ammonium ions inactivate the basic amino acid transport system in Schizosaccharomyces pombe in an irreversible manner. The inactivation is accompanied by a 4-fold decrease of KT of L-lysine transport, leaving its Jmax unchanged; phenylmethylsulfonyl fluoride protects the system against inactivation. In contrast, two basic amino acid transport systems in a gap1 mutant of Saccharomyces cerevisiae are influenced by NH4+ ions in such a way that only the Jmax decreases while the KT of L-lysine transport is unchanged. Phenylmethylsulfonyl fluoride does not act here as a protective agent.
Citace poskytuje Crossref.org
Thialysine-resistant mutants and uptake of lysine in Schizosaccharomyces pombe
