Enhancement of haemopoietic recovery in sublethally gamma-irradiated mice by the joint use of indomethacin and cystamine
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2279583
Knihovny.cz E-resources
- MeSH
- Cell Division drug effects MeSH
- Cystamine pharmacology MeSH
- Hematopoietic System drug effects radiation effects MeSH
- Indomethacin pharmacology MeSH
- Bone Marrow drug effects MeSH
- Mice MeSH
- Leukocyte Count drug effects MeSH
- Radiation-Protective Agents * MeSH
- Spleen drug effects MeSH
- Drug Synergism MeSH
- Organ Size drug effects MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cystamine MeSH
- Indomethacin MeSH
- Radiation-Protective Agents * MeSH
The effects of indomethacin and cystamine, administered prior to gamma-irradiation of mice, were investigated. Synergistic enhancement of haemopoietic recovery was observed under the conditions of a joint use of both drugs. The reason for this synergistic action is probably a joint operation of two mechanisms, i.e., the lowering of the radiosensitivity of haemopoietic stem cells by cystamine and the increase of the proliferation of surviving haemopoietic cells by indomethacin.
Stimulatory action of cyclooxygenase inhibitors on hematopoiesis: a review
