Immune protection of chickens conferred by a vaccine consisting of attenuated strains of Salmonella Enteritidis, Typhimurium and Infantis
Jazyk angličtina Země Velká Británie, Anglie Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
27741950
PubMed Central
PMC5065701
DOI
10.1186/s13567-016-0371-8
PII: 10.1186/s13567-016-0371-8
Knihovny.cz E-zdroje
- MeSH
- atenuované vakcíny terapeutické užití MeSH
- kombinované vakcíny terapeutické užití MeSH
- kur domácí imunologie mikrobiologie MeSH
- nemoci drůbeže imunologie prevence a kontrola MeSH
- Salmonella enteritidis imunologie MeSH
- Salmonella typhimurium imunologie MeSH
- Salmonella imunologie MeSH
- salmonelová infekce u zvířat imunologie mikrobiologie prevence a kontrola MeSH
- salmonelové vakcíny imunologie terapeutické užití MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- atenuované vakcíny MeSH
- kombinované vakcíny MeSH
- salmonelové vakcíny MeSH
The colonization of poultry with different Salmonella enterica serovars poses an issue throughout the world. In this study we therefore tested the efficacy of a vaccine consisting of attenuated strains of Salmonella enterica serovars Enteritidis, Typhimurium and Infantis against challenge with the same serovars and with S. Agona, Dublin and Hadar. We tested oral and aerosol administration of the vaccine, with or without co-administration of cecal microbiota from adult hens. The protective effect was determined by bacterial counts of the challenge strains up to week 18 of life and by characterizing the immune response using real-time PCR specific for 16 different genes. We have shown that a vaccine consisting of attenuated S. Enteritidis, S. Typhimurium and S. Infantis protected chickens against challenge with the wild type strains of the same serovars and partially protected chickens also against challenge with isolates belonging to serovars Dublin or Hadar. Aerosol vaccination was more effective at inducing systemic immunity whilst oral vaccination stimulated a local immune response in the gut. Co-administration of cecal microbiota increased the protectiveness in the intestinal tract but slightly decreased the systemic immune response. Adjusting the vaccine composition and changing the administration route therefore affects vaccine efficacy.
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