Inability of mitogen-stimulated spleen cells from newborn mice to synthesize interleukin-2 receptors
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články
PubMed
2279735
PubMed Central
PMC1384869
Knihovny.cz E-zdroje
- MeSH
- buněčné dělení imunologie MeSH
- imunologická tolerance MeSH
- inbrední kmeny myší MeSH
- konkanavalin A imunologie MeSH
- messenger RNA biosyntéza MeSH
- mitogeny imunologie MeSH
- myši inbrední AKR MeSH
- myši MeSH
- northern blotting MeSH
- novorozená zvířata imunologie MeSH
- receptory interleukinu-2 biosyntéza genetika MeSH
- slezina imunologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- konkanavalin A MeSH
- messenger RNA MeSH
- mitogeny MeSH
- receptory interleukinu-2 MeSH
Spleen cells from newborn mice do not respond by proliferation to concanavalin A (Con A) or bacterial lipopolysaccharide (LPS) stimulation. This non-reactivity cannot be reversed to a positive response by exogenous interleukin-2 (IL-2). The stimulation with Con A of spleen cells from newborn mice, in contrast to cells from adult animals, does not result in synthesis of mRNA for inducible 55,000 molecular weight (MW) IL-2 receptors (IL-2R). The failure of neonatal spleen cells to synthesize IL-2R mRNA is an intrinsic property of the cells themselves, and it is not due to activity of natural suppressor cells present in newborn animals. Since the expression of functional IL-2R represents one of the early and pivotal events in immune cell activation, we propose that the inability to synthesize IL-2R may be one of the primary reasons for the immunological immaturity of newborns.
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