Differences in the pore sizes of the N-methyl-D-aspartate and kainate cation channels
Language English Country Ireland Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
2458553
DOI
10.1016/0304-3940(88)90545-9
PII: 0304-3940(88)90545-9
Knihovny.cz E-resources
- MeSH
- Ion Channels metabolism physiology MeSH
- Cations metabolism MeSH
- Aspartic Acid analogs & derivatives metabolism pharmacology MeSH
- Kainic Acid metabolism pharmacology MeSH
- Brain cytology metabolism MeSH
- N-Methylaspartate MeSH
- Neurons metabolism MeSH
- Cell Membrane Permeability MeSH
- Strontium metabolism MeSH
- Calcium metabolism MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Ion Channels MeSH
- Cations MeSH
- Aspartic Acid MeSH
- Kainic Acid MeSH
- N-Methylaspartate MeSH
- Strontium MeSH
- Calcium MeSH
The cation channels in central nervous system neurons gated by the glutamate agonists N-methyl-D-aspartate (NMDA) and kainate have been shown to be similar, but not identical. To analyze the differences in more detail, the permeabilities of the channels to cations of different sizes have been measured. The kainate channel appears to be larger, and the cation permeabilities are similar to those of the acetylcholine gated channel at the neuromuscular junction. The NMDA channel appears to be about 10% smaller in size.
References provided by Crossref.org
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