Differences in the pore sizes of the N-methyl-D-aspartate and kainate cation channels

. 1988 Jul 08 ; 89 (3) : 313-8.

Jazyk angličtina Země Irsko Médium print

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid02458553
Odkazy

PubMed 2458553
DOI 10.1016/0304-3940(88)90545-9
PII: 0304-3940(88)90545-9
Knihovny.cz E-zdroje

The cation channels in central nervous system neurons gated by the glutamate agonists N-methyl-D-aspartate (NMDA) and kainate have been shown to be similar, but not identical. To analyze the differences in more detail, the permeabilities of the channels to cations of different sizes have been measured. The kainate channel appears to be larger, and the cation permeabilities are similar to those of the acetylcholine gated channel at the neuromuscular junction. The NMDA channel appears to be about 10% smaller in size.

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