Effects of single administration of scopolamine, physostigmine and their combination on biogenic amine levels in rat brain
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
2533807
Knihovny.cz E-zdroje
- MeSH
- fysostigmin farmakologie MeSH
- inbrední kmeny potkanů MeSH
- katecholaminy metabolismus MeSH
- krysa rodu Rattus MeSH
- mozek účinky léků metabolismus MeSH
- skopolamin farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- fysostigmin MeSH
- katecholaminy MeSH
- skopolamin MeSH
There were studied the changes of norepinephrine and dopamine levels in the brain cortex, the brain stem and hypothalamus of rats after the application of scopolamine, physostigmine and their combination. The application of scopolamine (0.5 mg/kg) or physostigmine (1.0 mg/kg) increased the levels of NE and in many cases statistically significantly. The simultaneous application of both drugs was manifested by less marked or neglectable changes of NE and DA levels in comparison with the control group.
