Effects of single administration of scopolamine, physostigmine and their combination on biogenic amine levels in rat brain
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2533807
Knihovny.cz E-resources
- MeSH
- Physostigmine pharmacology MeSH
- Rats, Inbred Strains MeSH
- Catecholamines metabolism MeSH
- Rats MeSH
- Brain drug effects metabolism MeSH
- Scopolamine pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Physostigmine MeSH
- Catecholamines MeSH
- Scopolamine MeSH
There were studied the changes of norepinephrine and dopamine levels in the brain cortex, the brain stem and hypothalamus of rats after the application of scopolamine, physostigmine and their combination. The application of scopolamine (0.5 mg/kg) or physostigmine (1.0 mg/kg) increased the levels of NE and in many cases statistically significantly. The simultaneous application of both drugs was manifested by less marked or neglectable changes of NE and DA levels in comparison with the control group.
