Alkaloids from Zephyranthes robusta BAKER and their acetylcholinesterase- and butyrylcholinesterase-inhibitory activity
Jazyk angličtina Země Švýcarsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
23776027
DOI
10.1002/cbdv.201200144
Knihovny.cz E-zdroje
- MeSH
- acetylcholinesterasa chemie metabolismus MeSH
- alkaloidy amarylkovitých chemie MeSH
- alkaloidy chemie izolace a purifikace metabolismus MeSH
- antioxidancia chemie izolace a purifikace MeSH
- butyrylcholinesterasa chemie metabolismus MeSH
- cholinesterasové inhibitory chemie izolace a purifikace metabolismus MeSH
- květy chemie MeSH
- liliovité chemie MeSH
- vazba proteinů MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 8-demethylmaritidine MeSH Prohlížeč
- acetylcholinesterasa MeSH
- alkaloidy amarylkovitých MeSH
- alkaloidy MeSH
- antioxidancia MeSH
- butyrylcholinesterasa MeSH
- cholinesterasové inhibitory MeSH
The bulbs of Zephyranthes robusta (Amaryllidaceae) have been extensively analyzed for their chemical constituents, resulting in the isolation of 13 alkaloids. The chemical structures of the isolated compounds were elucidated by mass-spectrometric, and 1D- and 2D-NMR spectroscopic experiments. The complete NMR assignments were achieved for hippeastidine. All isolated alkaloids were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibitory activities using the Ellman's method. Significant acetylcholinesterase inhibition activity was exhibited by 8-O-demethylmaritidine (IC₅₀ (HuAChE) 28.0±0.9 μM).
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