Alkaloids from Zephyranthes robusta BAKER and their acetylcholinesterase- and butyrylcholinesterase-inhibitory activity
Language English Country Switzerland Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Acetylcholinesterase chemistry metabolism MeSH
- Amaryllidaceae Alkaloids chemistry MeSH
- Alkaloids chemistry isolation & purification metabolism MeSH
- Antioxidants chemistry isolation & purification MeSH
- Butyrylcholinesterase chemistry metabolism MeSH
- Cholinesterase Inhibitors chemistry isolation & purification metabolism MeSH
- Flowers chemistry MeSH
- Liliaceae chemistry MeSH
- Protein Binding MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 8-demethylmaritidine MeSH Browser
- Acetylcholinesterase MeSH
- Amaryllidaceae Alkaloids MeSH
- Alkaloids MeSH
- Antioxidants MeSH
- Butyrylcholinesterase MeSH
- Cholinesterase Inhibitors MeSH
The bulbs of Zephyranthes robusta (Amaryllidaceae) have been extensively analyzed for their chemical constituents, resulting in the isolation of 13 alkaloids. The chemical structures of the isolated compounds were elucidated by mass-spectrometric, and 1D- and 2D-NMR spectroscopic experiments. The complete NMR assignments were achieved for hippeastidine. All isolated alkaloids were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibitory activities using the Ellman's method. Significant acetylcholinesterase inhibition activity was exhibited by 8-O-demethylmaritidine (IC₅₀ (HuAChE) 28.0±0.9 μM).
References provided by Crossref.org
Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper
Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors
