Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2534480
Knihovny.cz E-resources
- MeSH
- Leukocyte Common Antigens MeSH
- Antigens, Surface immunology MeSH
- Antigens, CD immunology MeSH
- Antigens, Differentiation, T-Lymphocyte immunology MeSH
- Antigens, Differentiation immunology MeSH
- Electrophoresis, Polyacrylamide Gel MeSH
- Glycoproteins immunology MeSH
- Hybridomas MeSH
- Humans MeSH
- Molecular Weight MeSH
- Antibodies, Monoclonal biosynthesis immunology MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Receptors, Lymphocyte Homing MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Leukocyte Common Antigens MeSH
- Antigens, Surface MeSH
- Antigens, CD MeSH
- Antigens, Differentiation, T-Lymphocyte MeSH
- Antigens, Differentiation MeSH
- Glycoproteins MeSH
- Antibodies, Monoclonal MeSH
- Receptors, Lymphocyte Homing MeSH
Monoclonal antibodies against several human leucocyte cell surface antigens were prepared and characterized: (1) MEM-56, MEM-93, MEM-66, and MEM-104 against the CD45R antigen (220 kDa and 205 kDa mol. wt. forms of the leucocyte common antigen CD45 expressed on B-lymphocytes, myeloid cells and a subpopulation of T-lymphocytes); (2) MEM-98 and MEM-100 against the T-lymphocyte antigen CD6 (mol. wt. 100 kDa); (3) MEM-85 against the broadly expressed antigen CD44 (mol. wt. 85 kDa) which was recently shown by us to be identical with the lymphocyte homing receptor; (4) MEM-53 against a newly described broadly expressed antigen of 35-40 kDa mol. wt. and (5) MEM-102 against another newly described glycoprotein of 40 kDa mol. wt. anchored in membrane through a phosphatidylinositol moiety.
The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1
