CD53 is an N-glycosylated pan-leucocyte antigen of 35-42,000 Mr. The sequence of the CD53 polypeptide deduced from a cDNA clone is 219 amino acids in length. It appears to lack a conventional leader sequence because the deduced NH2-terminal amino acid sequence is very similar to the rat MRC OX-44 and human CD37 antigens. The CD53 molecule is likely to consist of four transmembrane regions and a major extracellular hydrophilic loop containing two potential N-glycosylation sites. It is suggested that the CD53 glycoprotein is the true human homologue of the rat OX-44 antigen, rather than the CD37 antigen of more restricted expression and lower NH2-terminal sequence similarity to OX-44.

Institute of Molecular Genetics Czechoslovak Academy of Sciences Praha

Zobrazit více v PubMed

Mol Immunol. 1989 Feb;26(2):153-61 PubMed

J Exp Med. 1987 Jan 1;165(1):1-13 PubMed

J Mol Biol. 1982 May 5;157(1):105-32 PubMed

Cancer Res. 1988 Jun 1;48(11):2955-62 PubMed

Proc Natl Acad Sci U S A. 1989 Dec;86(23):9089-93 PubMed

J Exp Med. 1988 Jun 1;167(6):1975-80 PubMed

Nucleic Acids Res. 1986 Jan 10;14(1):217-31 PubMed

Proc Natl Acad Sci U S A. 1987 May;84(10):3365-9 PubMed

J Biol Chem. 1988 Sep 5;263(25):12163-6 PubMed

Anal Biochem. 1984 Feb;136(2):458-64 PubMed

Folia Biol (Praha). 1989;35(5):289-97 PubMed

Immunogenetics. 1989;30(3):162-8 PubMed

J Exp Med. 1989 Apr 1;169(4):1497-502 PubMed

Tetraspanin CD53 Promotes Inflammation but Restrains Mucus Production in a Mouse Model of Allergic Airway Inflammation

Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins

Genomic structure of the human CD53 gene

Zobrazit více v PubMed

GENBANK
M37033