Supercoil-induced Z-DNA formation within 5'-end of chicken myb proto-oncogene

. 1989 Feb 15 ; 158 (3) : 737-42.

Jazyk angličtina Země Spojené státy americké Médium print

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid02645867
Odkazy

PubMed 2645867
DOI 10.1016/0006-291x(89)92783-6
PII: 0006-291X(89)92783-6
Knihovny.cz E-zdroje

We have analyzed the recently sequenced and characterized 2.9 kb fragment derived from the 5'-end of chicken myb proto-oncogene with respect to structural perturbations induced by DNA supercoiling. Within the first intron a 50 bp sequence stretch was localized, starting approximately 450 nucleotides downstream from putative ATG initiation codon, which forms a non-B-DNA structure. Fine mapping with structural probes revealed the three adjacent regions with imperfect purine-pyrimidine alternation creating together relatively long Z-forming tract, parts of which may undergo a B-Z DNA transition at different superhelical densities.

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Transcription of the chicken myb proto-oncogene starts within a CpG island

. 1989 Jul 25 ; 17 (14) : 5651-64.

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