Effect of indomethacin, diclofenac sodium and sodium salicylate on peripheral blood cell counts in sublethally gamma-irradiated mice
Language English Country Germany Media print
Document type Comparative Study, Journal Article
PubMed
2772821
Knihovny.cz E-resources
- MeSH
- Time Factors MeSH
- Diclofenac pharmacology therapeutic use MeSH
- Radiation Injuries, Experimental blood drug therapy MeSH
- Hematopoiesis drug effects MeSH
- Indomethacin pharmacology therapeutic use MeSH
- Blood Cell Count MeSH
- Mice, Inbred C57BL MeSH
- Mice, Inbred CBA MeSH
- Mice MeSH
- Sodium Salicylate pharmacology therapeutic use MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Diclofenac MeSH
- Indomethacin MeSH
- Sodium Salicylate MeSH
Treatment with indomethacin and diclofenac sodium was found to increase granulocyte counts in the blood of sublethally gamma-irradiated mice. Treatment with sodium salicylate was ineffective in this respect, administration of sodium salicylate together with indomethacin even decreased the indomethacin-induced effects. The results suggest that the hemopoiesis-stimulating effects of non-steroidal anti-inflammatory drugs cannot be correlated with the anti-inflammatory activity but rather with the side effects of these compounds, including the action on gastro-intestinal prostanoid production. This conclusion doubts on the possibility of the usefulness of non-steroidal anti-inflammatory drugs in conditions of the radiation syndrome.
Stimulatory action of cyclooxygenase inhibitors on hematopoiesis: a review
