Distribution of phenylethanolamine-N-methyltransferase in the rat heart: effect of 6-hydroxydopamine
Language English Country Netherlands Media print
Document type Journal Article
PubMed
3119356
DOI
10.1016/0014-2999(87)90276-7
PII: 0014-2999(87)90276-7
Knihovny.cz E-resources
- MeSH
- Epinephrine metabolism MeSH
- Phenylethanolamine N-Methyltransferase metabolism MeSH
- Hydroxydopamines pharmacology MeSH
- Rats, Inbred Strains MeSH
- Rats MeSH
- Myocardium metabolism MeSH
- Norepinephrine metabolism MeSH
- Oxidopamine MeSH
- Heart drug effects MeSH
- Tissue Distribution MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Epinephrine MeSH
- Phenylethanolamine N-Methyltransferase MeSH
- Hydroxydopamines MeSH
- Norepinephrine MeSH
- Oxidopamine MeSH
The distribution of phenylethanolamine-N-methyltransferase (PNMT), the epinephrine-forming enzyme in the adult rat heart atria and ventricles was studied. The activity of the enzyme in the hearts of adult rats is very low; a significantly higher activity was found in the atria than in the ventricles. A significant increase in PNMT activity was found in all heart areas examined in 6-hydroxydopamine-treated rats compared to vehicle-treated rats. The increased PNMT activity might reflect compensatory or adaptation processes secondary to the destruction of the peripheral sympathetic nerve terminals.
References provided by Crossref.org
Catecholaminergic neurons in the rat intrinsic cardiac nervous system
