Distribution of phenylethanolamine-N-methyltransferase in the rat heart: effect of 6-hydroxydopamine
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články
PubMed
3119356
DOI
10.1016/0014-2999(87)90276-7
PII: 0014-2999(87)90276-7
Knihovny.cz E-zdroje
- MeSH
- adrenalin metabolismus MeSH
- fenylethanolamin-N-methyltransferasa metabolismus MeSH
- hydroxydopaminy farmakologie MeSH
- inbrední kmeny potkanů MeSH
- krysa rodu Rattus MeSH
- myokard metabolismus MeSH
- noradrenalin metabolismus MeSH
- oxidopamin MeSH
- srdce účinky léků MeSH
- tkáňová distribuce MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adrenalin MeSH
- fenylethanolamin-N-methyltransferasa MeSH
- hydroxydopaminy MeSH
- noradrenalin MeSH
- oxidopamin MeSH
The distribution of phenylethanolamine-N-methyltransferase (PNMT), the epinephrine-forming enzyme in the adult rat heart atria and ventricles was studied. The activity of the enzyme in the hearts of adult rats is very low; a significantly higher activity was found in the atria than in the ventricles. A significant increase in PNMT activity was found in all heart areas examined in 6-hydroxydopamine-treated rats compared to vehicle-treated rats. The increased PNMT activity might reflect compensatory or adaptation processes secondary to the destruction of the peripheral sympathetic nerve terminals.
Citace poskytuje Crossref.org
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