Effect of lomustin on some platelet functions in vitro
Language English Country Slovakia Media print
Document type Journal Article
Persistent link
https://www.medvik.cz/link/pmid03696302
PubMed
3696302
Knihovny.cz E-resources
- MeSH
- Adenosine Diphosphate pharmacology MeSH
- Epinephrine pharmacology MeSH
- Platelet Aggregation drug effects MeSH
- Serotonin Antagonists pharmacology MeSH
- Collagen pharmacology MeSH
- Humans MeSH
- Lomustine pharmacology MeSH
- Clot Retraction MeSH
- Platelet Factor 3 antagonists & inhibitors MeSH
- Platelet Factor 4 antagonists & inhibitors MeSH
- Blood Platelets drug effects MeSH
- Platelet Function Tests * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Adenosine Diphosphate MeSH
- Epinephrine MeSH
- Serotonin Antagonists MeSH
- Collagen MeSH
- Lomustine MeSH
- Platelet Factor 3 MeSH
- Platelet Factor 4 MeSH
The effect of lomustin on platelet functions was investigated in vitro using a wide battery of tests. Lomustin was found to act as a specific inhibitor of platelet aggregation, release reaction and clot retraction and to induce acquired thrombocytopathy. Thus, impairment of platelet functions might play a role in hemorrhagic complications accompanying lomustin therapy in some cases.
