The uvrE (E. coli KS 114) cells carry a mutation in the gene that codes for helicase II. This is the protein responsible for replicative unwinding of double-helical DNA. The repair mode of such cells may be altered as compared with the wild type. The survival of uvrE cells during postirradiation incubation under inhibition of de novo protein synthesis was increased which indicates that this process of repair in uvrE cells is mediated by constitutive proteins and does not require any inducible products but takes a certain time. This inhibition of de novo protein synthesis causes also an inhibition of dimer excision, an increase of the parental DNA degradation and a decrease of parental and daughter DNA molar mass. On the other hand, it seems that induced proteins are formed in uvrE cells after UV irradiation but their influence is low in inducible repair and they can act only under conditions of complete protein synthesis.

Zobrazit více v PubMed

Mol Gen Genet. 1980;180(1):185-91 PubMed

J Bacteriol. 1983 Mar;153(3):1172-9 PubMed

Genetika. 1976;12(4):100-8 PubMed

J Bacteriol. 1980 May;142(2):535-46 PubMed

Gene. 1983 Nov;25(2-3):317-23 PubMed

Eur J Biochem. 1977 Sep 15;79(1):33-8 PubMed

Cell. 1982 May;29(1):11-22 PubMed

J Gen Microbiol. 1973 Jun;76(2):407-16 PubMed

Mol Gen Genet. 1979 Oct 2;176(1):1-9 PubMed

Eur J Biochem. 1982 Jun 15;125(1):63-8 PubMed

Nature. 1982 Jul 1;298(5869):98-100 PubMed

Eur J Biochem. 1976 Jun 1;65(2):431-40 PubMed

Mutat Res. 1982 Jun;94(2):285-97 PubMed

Mol Gen Genet. 1981;184(3):526-30 PubMed

Mol Gen Genet. 1983;189(1):157-61 PubMed

Folia Microbiol (Praha). 1966;11(3):169-72 PubMed

J Bacteriol. 1973 Jan;113(1):145-60 PubMed

Nucleic Acids Res. 1983 Apr 11;11(7):2193-204 PubMed

J Bacteriol. 1973 Jan;113(1):161-6 PubMed

Mol Gen Genet. 1978 Mar 20;160(1):81-7 PubMed

Proc Natl Acad Sci U S A. 1982 Sep;79(18):5616-20 PubMed

Eur J Biochem. 1983 Dec 15;137(3):573-80 PubMed

Mutat Res. 1981 Dec;84(2):257-62 PubMed

Mol Gen Genet. 1973;123(1):89-110 PubMed

Mol Gen Genet. 1983;190(2):265-70 PubMed

Mol Gen Genet. 1975 Aug 27;139(3):233-43 PubMed

Mol Gen Genet. 1977 Oct 24;155(3):267-77 PubMed

J Biol Chem. 1980 Oct 25;255(20):9746-52 PubMed

Mol Gen Genet. 1981;184(2):191-9 PubMed

Mol Gen Genet. 1971;113(3):217-21 PubMed

Mutat Res. 1974 Dec;25(3):273-9 PubMed

Gene. 1983 Nov;25(2-3):309-16 PubMed

Annu Rev Biochem. 1979;48:783-836 PubMed

Nature. 1966 Oct 29;212(5061):534-5 PubMed

Gene. 1982 Oct;19(3):285-95 PubMed

Mol Gen Genet. 1968 May 3;101(3):227-44 PubMed