Changes in the migratory activity of polymorphonuclear leukocytes after administration of Freund's adjuvant
Language English Country United States Media print
Document type Journal Article
PubMed
3924799
DOI
10.1007/bf02923514
Knihovny.cz E-resources
- MeSH
- Adjuvants, Immunologic immunology MeSH
- Chemotactic Factors biosynthesis MeSH
- Chemotaxis, Leukocyte * MeSH
- Endotoxins immunology MeSH
- Escherichia coli immunology MeSH
- Rabbits MeSH
- Listeria monocytogenes immunology MeSH
- Neutrophils immunology MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Adjuvants, Immunologic MeSH
- Chemotactic Factors MeSH
- Endotoxins MeSH
Spontaneous and chemotactic activity of polymorphonuclear leukocytes, obtained from the peritoneal cavity, was studied after administration of complete and incomplete Freund's adjuvant to rabbits at intervals of 18-26 d after adjuvant injection. Whereas injection of both complete and incomplete adjuvant increased spontaneous migration of rabbit polymorphonuclear leukocytes, the migration directed by the chemotactic signal, induced in fresh serum by E. coli endotoxin, was decreased. The chemotaxigenic activity of two factors, isolated from cell walls of Listeria monocytogenes was also tested: factor Ei (its most potent component is lipopolysaccharide) and a purified phenol extract of lipopeptidopolysaccharide nature.
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