Hierarchy of the B (MHC) haplotypes controlling resistance to rous sarcomas in a model of inbred lines of chickens
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
6097482
Knihovny.cz E-zdroje
- MeSH
- hlavní histokompatibilní komplex * MeSH
- kur domácí imunologie MeSH
- MHC antigeny II. třídy genetika MeSH
- přirozená imunita MeSH
- ptačí sarkom imunologie patologie MeSH
- viry ptačího sarkomu MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- MHC antigeny II. třídy MeSH
The effects of individual B haplotypes on regression of Rous sarcoma virus-induced tumours were studied in a genetically defined model of congenic chicken lines differing at the B complex (MHC). Regression of Rous sarcomas is genetically controlled mainly by B genes the effects of which are qualitative in nature. In the model described which encompassed congenic inbred lines and their F1 hybrids and a number of various combinations of progeny from backcross matings, the genetic interactions among individual B haplotypes and the modifying influence of the genetic background, as manifested by quantitative variability of tumour growth parameters, could also be investigated. Some specific combinations of backcross progeny exhibited significant shifts with regard to basic classification of the degree of resistance of groups with a given B genotype in the congenic lines and their F1 hybrids. Based on these differences, further more detailed studies of the complex genetic mechanism operative in the control of tumour growth may be undertaken. Discriminant analysis, as part of the known series of the biomedical programs BMDP75, was used to evaluate the results.
Inhibition of autoimmune Chagas-like heart disease by bone marrow transplantation
src-specific immunity in inbred chickens bearing v-src DNA- and RSV-induced tumors