Mice of the inbred strain C57BL/10ScSn compared to the A/J strain produce ten times fewer IgG plaque-forming cells and serum IgG antibodies after primary and secondary SRBC immunization. Even after a repeated immunization with SRBC, the titres of IgG anti SRBC antibodies in serum do not reach the levels found in A/J mice. On the other hand, IgM anti SRBC antibodies are higher in C57BL/10ScSn mice and remain high, even after repeated immunization. Doses of antigen ranging from 1 X 10(7) to 1 X 10(10) SRBC per mouse i.p. did not change significantly the response of C57BL/10ScSn mice. Only the highest dose slightly increased IgG anti SRBC antibody production. The use of a soluble erythrocyte antigen with similar antigenic properties as the original corpuscular form did not change the nature of IgM and IgG anti SRBC antibody response.

Low IgG response of the mouse strain C57BL/10ScSn after immunization with protein antigens