Does the transcription factor c-ets1 take part in the regulation of angiogenesis and tumor invasion?
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
7534726
Knihovny.cz E-zdroje
- MeSH
- patologická angiogeneze * patofyziologie MeSH
- protoonkogenní protein c-ets-1 MeSH
- protoonkogenní proteiny c-ets MeSH
- protoonkogenní proteiny genetika metabolismus MeSH
- protoonkogeny fyziologie MeSH
- transkripční faktory genetika metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- protoonkogenní protein c-ets-1 MeSH
- protoonkogenní proteiny c-ets MeSH
- protoonkogenní proteiny MeSH
- transkripční faktory MeSH
The c-ets1 proto-oncogene encodes a transcription factor that binds a GGAA/T purine rich core DNA sequence. During normal as well as pathological development, the expression of c-ets1 is associated with the occurrence of invasive processes, either in invading cells or in the invaded tissue. Cellular regulatory sequences responsive to the c-Ets1 proteins include a urokinase-type plasminogen activator (u-PA) gene enhancer, the stromelysin-1 and the collagenase-1 gene promoters. Since invasive processes are thought to require the remodeling of the extra-cellular matrix, we investigate the relationships between c-Ets1 and the expression pattern of transcripts encoding these matrix degrading proteases, in embryos and in solid tumors.
