Anabolic effects of progestogens in bone remodelling
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
8711371
Knihovny.cz E-resources
- MeSH
- Alkaline Phosphatase metabolism MeSH
- Estradiol administration & dosage MeSH
- Hydroxyproline urine MeSH
- Bone and Bones enzymology MeSH
- Bone Density MeSH
- Humans MeSH
- Follow-Up Studies MeSH
- Norethindrone administration & dosage MeSH
- Norpregnenes administration & dosage MeSH
- Osteoporosis etiology physiopathology MeSH
- Ovariectomy adverse effects MeSH
- Progestins pharmacology physiology MeSH
- Prospective Studies MeSH
- Bone Remodeling drug effects MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Alkaline Phosphatase MeSH
- Estradiol MeSH
- Hydroxyproline MeSH
- Norethindrone MeSH
- Norpregnenes MeSH
- Progestins MeSH
- tibolone MeSH Browser
The short-term effects of oestrogen deficiency on biochemical indices of bone turnover were studied in 49 women who had undergone hysterectomy with bilateral ovariectomy. In patients treated with norethisterone or tibolone, a significant reduction was observed in urinary hydroxyproline excretion comparable to that observed in estradiol treated patients. Bone isoenzyme of serum alkaline phosphatase activity did not decrease and bone mass remained increased during norethisterone and tibolone treatments. It is concluded that norethisterone and tibolone can act as bone-trophic hormones.
