• Keywords
• relugolix, Reygo, studie LIBERTY 1, studie LIBERTY 2,
• MeSH
• Hormone Antagonists administration & dosage   therapeutic use   MeSH
• Adult MeSH
• Estradiol administration & dosage   therapeutic use   MeSH
• Drug Therapy, Combination MeSH
• Leiomyomatosis * diagnosis   complications   MeSH
• Humans MeSH
• Norethindrone Acetate administration & dosage   therapeutic use   MeSH
• Randomized Controlled Trials as Topic MeSH
• Treatment Outcome MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Case Reports MeSH
• Geographicals
• Czech Republic MeSH

• Keywords
• relugolix,
• MeSH
• Androgen Antagonists pharmacology   therapeutic use   MeSH
• Adult MeSH
• Estradiol pharmacology   therapeutic use   MeSH
• Drug Therapy, Combination MeSH
• Leiomyoma * surgery   drug therapy   MeSH
• Humans MeSH
• Norethindrone Acetate pharmacology   therapeutic use   MeSH
• Randomized Controlled Trials as Topic MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Female MeSH

• MeSH
• Androgens * administration & dosage   pharmacology   adverse effects   MeSH
• Contraception * methods   adverse effects   MeSH
• Adult MeSH
• Outcome Assessment, Health Care * MeSH
• Injections, Intramuscular MeSH
• Drug Therapy, Combination MeSH
• Contraceptive Agents * administration & dosage   pharmacology   adverse effects   MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Norethindrone * analogs & derivatives   administration & dosage   pharmacology   adverse effects   MeSH
• Prospective Studies MeSH
• Spermatogenesis * drug effects   MeSH
• Pregnancy MeSH
• Testosterone * analogs & derivatives   administration & dosage   pharmacology   adverse effects   MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Pregnancy MeSH
• Female MeSH
• Publication type
• Overall MeSH

• MeSH
• Dydrogesterone administration & dosage   therapeutic use   MeSH
• Estradiol administration & dosage   adverse effects   therapeutic use   MeSH
• Hormone Replacement Therapy methods   MeSH
• Middle Aged MeSH
• Humans MeSH
• Norethindrone administration & dosage   adverse effects   therapeutic use   MeSH
• Postmenopause drug effects   MeSH
• Osteoporosis, Postmenopausal prevention & control   MeSH
• Aged MeSH
• Dose-Response Relationship, Drug MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Aged MeSH
• Female MeSH

• MeSH
• Contraceptives, Oral, Hormonal administration & dosage   pharmacology   therapeutic use   MeSH
• Middle Aged MeSH
• Humans MeSH
• Menstruation drug effects   MeSH
• Norethindrone administration & dosage   pharmacology   therapeutic use   MeSH
• Perimenopause drug effects   MeSH
• Postmenopause drug effects   MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Female MeSH

Autoři v přehledovém článku shrnují současné možnosti mužské antikoncepce. Růst celosvětové populace a jeho dopad na životní prostředí a ekonomiku, především v rozvojových zemích, vyvolává globální potřebu podporovat jednotlivce při plánování rodiny. Zdravotnické organizace a farmaceutické společnosti jsou si této zodpovědnosti vědomy a finančně i logisticky podporují výzkum nových metod antikoncepce. Hormonální antikoncepce působí inhibicí spermatogeneze jako efektivní a reverzibilní antikoncepční metoda. Některé nehormonální přístupy k mužské antikoncepci mají překvapivé a slibné výsledky a mohou se stát základem pro vývoj nových metod. Přes poznatky v oblasti molekulární charakterizace pohlavních buněk a s tím spojené možnosti potlačení jejich proliferace, motility nebo schopnosti vazby gamet není žádná z dosud publikovaných metod kontracepce 100% funkční a použitelná pro všechny muže ve světové populaci a nezajišťuje plnou reverzibilitu u navozené neplodnosti. Jedinou bezpečnou a spolehlivou metodou tak zůstává vazektomie.

• Keywords
• Zavesca, Intra Vas Device, Vasclip,
• MeSH
• 1-Deoxynojirimycin pharmacology   MeSH
• Contraceptive Devices, Male classification   statistics & numerical data   MeSH
• Cyproterone Acetate pharmacology   MeSH
• Desogestrel pharmacology   MeSH
• Gossypol pharmacology   MeSH
• Contraceptive Agents, Male pharmacology   classification   MeSH
• Levonorgestrel pharmacology   MeSH
• Medroxyprogesterone Acetate pharmacology   MeSH
• Nifedipine pharmacology   MeSH
• Norethindrone analogs & derivatives   MeSH
• Prostheses and Implants classification   MeSH
• Tripterygium chemistry   MeSH
• Vasectomy methods   statistics & numerical data   MeSH
• Check Tag
• Male MeSH
• Publication type
• Review MeSH

• MeSH
• Adult MeSH
• Estradiol administration & dosage   pharmacology   therapeutic use   MeSH
• Drug Combinations MeSH
• Hormone Replacement Therapy methods   utilization   MeSH
• Endometrial Hyperplasia drug therapy   prevention & control   therapy   MeSH
• Climacteric physiology   drug effects   MeSH
• Humans MeSH
• Norethindrone analogs & derivatives   pharmacology   therapeutic use   MeSH
• Osteoporosis drug therapy   prevention & control   MeSH
• Postmenopause physiology   drug effects   MeSH
• Treatment Outcome MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Randomized Controlled Trial MeSH

• MeSH
• Densitometry utilization   MeSH
• Adult MeSH
• Estradiol administration & dosage   therapeutic use   MeSH
• Drug Combinations MeSH
• Humans MeSH
• Norethindrone analogs & derivatives   administration & dosage   therapeutic use   MeSH
• Osteoporosis, Postmenopausal drug therapy   prevention & control   therapy   MeSH
• Primary Prevention MeSH
• Treatment Outcome MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Case Reports MeSH

• MeSH
• Anilides pharmacology   MeSH
• Androgen Antagonists pharmacology   MeSH
• Research Support as Topic MeSH
• Mammary Glands, Animal drug effects   MeSH
• Mice MeSH
• Norethindrone analogs & derivatives   MeSH
• Seminal Vesicles drug effects   MeSH
• Spleen drug effects   MeSH
• Steroids pharmacology   MeSH
• Animals MeSH
• Check Tag
• Male MeSH
• Mice MeSH
• Animals MeSH

• MeSH
• Estradiol analogs & derivatives   administration & dosage   MeSH
• Injections utilization   MeSH
• Contraceptive Agents, Female administration & dosage   adverse effects   MeSH
• Humans MeSH
• Adolescent MeSH
• Norethindrone analogs & derivatives   administration & dosage   MeSH
• Check Tag
• Humans MeSH
• Adolescent MeSH
• Female MeSH