Comparison of the effects of a low-protein diet with the effects of a converting enzyme inhibitor on the progression of renal insufficiency in hypertensive rats
Language English Country Great Britain, England Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Antihypertensive Agents therapeutic use MeSH
- Time Factors MeSH
- Enalapril therapeutic use MeSH
- Hypertension metabolism therapy MeSH
- Angiotensin-Converting Enzyme Inhibitors therapeutic use MeSH
- Combined Modality Therapy MeSH
- Rats MeSH
- Nephrectomy MeSH
- Diet, Protein-Restricted * MeSH
- Rats, Inbred SHR MeSH
- Drug Evaluation, Preclinical MeSH
- Disease Progression MeSH
- Renal Insufficiency metabolism therapy MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Antihypertensive Agents MeSH
- Enalapril MeSH
- Angiotensin-Converting Enzyme Inhibitors MeSH
The beneficial effects of a low-protein diet vs. angiotensin-converting enzyme inhibitor (ACEI, enalapril) on the course of ablation nephropathy (5/6 nephrectomy, 5/6NX) were compared in a new strain of genetic hypertensive rats, the Prague hypertensive rat (PHR). Both maneuvers were followed by a significant drop in proteinuria (1.27 and 8.8 vs. 56.2 mg/24 hod, p < 0.001, low-protein diet vs. ACEI vs. untreated), plasma levels of creatinine (175.3 and 177.1 vs. 245.3 mumol/L, p < 0.001) and urea (7.95 and 13.51 vs. 37.6 mmol/L, p < 0.001). Endogenous creatinine clearance was higher after both low-protein diet and ACEI than without them (134.6 and 127.8 vs. 56.7 microL/min/100 g BW, p < 0.001). Both maneuvers had a similar beneficial effect: no additional amelioration was observed with a combination of both low-protein diet and ACEI. Compared to normotensive Wistar rats, the results were quite similar in PHR except the blood pressure values; hypertension had no substantial effect on the course of 5/6NX or on the beneficial action of both low-protein diet and ACEI.
References provided by Crossref.org
Research on Experimental Hypertension in Prague (1966-2009)
