Characterization of the limited specificity of antigen recognition in earthworms
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
8763159
DOI
10.1007/bf02814753
Knihovny.cz E-resources
- MeSH
- Adjuvants, Immunologic pharmacology MeSH
- Epitopes MeSH
- Haptens pharmacology MeSH
- Immunization MeSH
- Arsanilic Acid pharmacology MeSH
- Oligochaeta immunology MeSH
- Proteins immunology MeSH
- Serum Albumin pharmacology MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Adjuvants, Immunologic MeSH
- Epitopes MeSH
- Haptens MeSH
- Arsanilic Acid MeSH
- Proteins MeSH
- Serum Albumin MeSH
Earthworms respond to parenteral stimulation with a protein antigen by the formation of an antigen-binding protein. Earthworms were parenterally stimulated with different proteins and the protein binding was estimated in vitro on both humoral and cellular levels. The binding was significantly higher when the same protein was used for in vivo stimulation. The degree of specificity of the antigen-binding protein after the secondary in vivo challenge increased, but even so it was considerably lower than that of vertebrate immunoglobulins.
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Characterization of the limited specificity of antigen recognition in earthworms
