Successful HLA-identical sibling cord blood transplantation in a 6-year-old boy with leukocyte adhesion deficiency syndrome
Language English Country England, Great Britain Media print
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
PubMed
8832030
Knihovny.cz E-resources
- MeSH
- Chimera MeSH
- Child MeSH
- Fetal Blood cytology MeSH
- Histocompatibility MeSH
- Immunophenotyping MeSH
- Leukocyte-Adhesion Deficiency Syndrome diagnosis therapy MeSH
- Humans MeSH
- Fetal Diseases diagnosis MeSH
- Infant, Newborn MeSH
- Nuclear Family MeSH
- Cordocentesis MeSH
- Transplantation Conditioning MeSH
- Hematopoietic Stem Cell Transplantation * MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Male MeSH
- Infant, Newborn MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
A 6-year-old boy with the severe form of the leukocyte adhesion deficiency syndrome (LAD) received a transplant of cord blood (CBT) from his HLA-identical brother. The donor was proved healthy by successful prenatal diagnosis. CBT was performed after conditioning with etoposide, busulfan and cyclophosphamide. After hematopoietic recovery complete chimerism was proved as well as the normal expression of CD11x/CD18 complex on circulating leukocytes. The only post-transplant complication was a mild pneumonitis resolving on the corticosteroid therapy. Thirteen months after CBT the boy is in good health and shows no signs of immunodeficiency. As far as we know this is the first report of successful CBT in a patient with LAD syndrome.
