The immune response against Francisella tularensis live vaccine strain in Lps(n) and Lps(d) mice
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8861035
DOI
10.1111/j.1574-695x.1996.tb00243.x
PII: 0928-8244(95)00110-7
Knihovny.cz E-resources
- MeSH
- Vaccines, Attenuated immunology MeSH
- Bacterial Vaccines classification immunology MeSH
- Killer Cells, Natural immunology metabolism MeSH
- Cytokines biosynthesis MeSH
- Francisella tularensis immunology MeSH
- Macrophages immunology metabolism MeSH
- Mice, Mutant Strains MeSH
- Mice, Inbred C3H MeSH
- Mice MeSH
- Nitric Oxide biosynthesis MeSH
- Antibodies, Bacterial biosynthesis MeSH
- Tularemia immunology prevention & control MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Vaccines, Attenuated MeSH
- Bacterial Vaccines MeSH
- Cytokines MeSH
- Nitric Oxide MeSH
- Antibodies, Bacterial MeSH
The impact of Lps gene on the course of immune response against subcutaneous infection of mice with Francisella tularensis live vaccine strain was studied. Production and specificity of antibodies, cytotoxic responses of macrophages and NK-cells, spontaneous production ex vivo of cytokines IL-1 alpha, IL-2, IL-4, IL-6, IL-10, IFN-gamma, and TNF-alpha in spleen cell cultures in C3H/HeJ (Lps(d)) mice in comparison with C3H/HeN (Lps(n)) mice were tested. The value of LD(50) was significantly different in the two strains of mice (8.0 x 10(5) cfu for C3H/HeJ versus 4.61 x 10(3) cfu for C3H/HeJ mice after subcutaneous inoculation). The production of NO(2) is also impaired in C3H/HeJ mice in the early intervals after infection. Thus, the defective Lps gene of C3H/HeJ mice influences both the level of innate resistance of mice to F. tularensis live vaccine strain infection and the process of induction and regulation of immune response against this intracellular bacterial pathogen.
References provided by Crossref.org
Early infection-induced natural antibody response
