Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, U.S. Gov't, P.H.S.
Grantová podpora
HL-35018
NHLBI NIH HHS - United States
PubMed
9045857
PubMed Central
PMC507837
DOI
10.1172/jci119198
Knihovny.cz E-zdroje
- MeSH
- druhová specificita MeSH
- genotyp MeSH
- hypertenze genetika patologie patofyziologie MeSH
- krevní tlak genetika MeSH
- krysa rodu Rattus MeSH
- mapování chromozomů * MeSH
- molekulární sekvence - údaje MeSH
- potkani inbrední BN MeSH
- potkani inbrední SHR MeSH
- velikost orgánu genetika MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
The spontaneously hypertensive rat (SHR) is the most widely studied animal model of essential hypertension. Despite > 30 yr of research, the primary genetic lesions responsible for hypertension in the SHR remain undefined. In this report, we describe the construction and hemodynamic characterization of a congenic strain of SHR (SHR-Lx) that carries a defined segment of chromosome 8 from a normotensive strain of Brown-Norway rats (BN-Lx strain). Transfer of this segment of chromosome 8 from the BN-Lx strain onto the SHR background resulted in substantial reductions in systolic and diastolic blood pressure and cardiac mass. Linkage and comparative mapping studies indicate that the transferred chromosome segment contains a number of candidate genes for hypertension, including genes encoding a brain dopamine receptor and a renal epithelial potassium channel. These findings demonstrate that BP regulatory gene(s) exist within the differential chromosome segment trapped in the SHR-Lx congenic strain and that this region of chromosome 8 plays a major role in the hypertension of SHR vs. BN-Lx rats.
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Linkage mapping of the mixed-lineage leukemia (Mll) gene to rat chromosome 8
GENBANK
M36831, X72341
