Accumulation of Ade+ reversions in isoauxotrophic stains of Saccharomyces cerevisiae allelic in RAD6 during adenine starvation
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
9161002
Knihovny.cz E-zdroje
- MeSH
- adenin metabolismus MeSH
- alely MeSH
- geny hub MeSH
- ligasy genetika MeSH
- mutace MeSH
- oprava DNA MeSH
- Saccharomyces cerevisiae - proteiny * MeSH
- Saccharomyces cerevisiae genetika metabolismus MeSH
- ubikvitin konjugující enzymy MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adenin MeSH
- ligasy MeSH
- RAD6 protein, S cerevisiae MeSH Prohlížeč
- Saccharomyces cerevisiae - proteiny * MeSH
- ubikvitin konjugující enzymy MeSH
A comparative method based on an analysis of accumulation of starvation-induced Ade+ reversions and cell death during adenine starvation was developed and exploited for estimating the role of RAD6 in the starvation-induced reversions. It was shown that inactivation of RAD6 function in Saccharomyces cerevisiae markedly enhances the accumulation of Ade+ reversions, and therefore it is likely that this gene is taking part in maintaining the low level of starvation-induced mutations in yeast cells.
